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All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo
Andi Kurnia Bintang
Hasanuddin University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Transcranial Magnetic Stimulation Can Improve Cognitive Function and Brain-Derived Neurotrophic Peptide Levels in Post-Ischemic Stroke Patients Ulima Rahma Asri; Jumraini Tammasse; Andi Kurnia Bintang; Rina Masadah; Muhammad Akbar; David Gunawan Umbas
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.41

Abstract

ABSTRACT Background: Stroke can cause a significant burden of morbidity, including complications of impaired cognitive function. The problem being investigated is hypothesized to be related to brain-derived neurotrophic factor (BDNF), which can be increased by repetitive transcranial magnetic stimulation (rTMS). Purpose(s): To evaluate the effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on serum BDNF levels and cognitive function in ischemic stroke patients. Methods: A pre-test post-test control group, experimental study design, was applied to research conducted at Dr Wahidin Sudirohusodo Makassar and network hospitals in June 2023 until the sample size was met. All ischemic stroke patients who experienced impaired memory function were divided into control (medicamentous, n=10) and treatment (medicamentous + rTMS, n=11). Both at baseline and 14 days following therapy, their BDNF levels and MoCA-INA scores were assessed. ELISA examination is used to measure BDNF levels. The dependent T-test was used to analyze changes in MoCA-INA and BDNF scores in each group. Results: In the treatment group, the median MoCA INA score (26.00 (18.00-28.00) vs. 16.00 (13.00-21.00; p=0.001)) and BDNF levels (1.66 (0.78-3.59) vs. 1.55 (0.01-2.76); p=0.002) increased in two weeks. In contrast, the MoCA-INA score and BDNF levels in the control group did not show a statistically significant difference over a two-week period. MoCA-INA scores and BDNF levels in the treatment group showed a significant and favorable correlation, but not in the control group. Conclusion: rTMS can improve patients' cognitive function after ischemic stroke by improving BDNF levels. Keywords: Brain-derived neurotrophic factor, cognitive function, ischaemic stroke, repetitive transcranial magnetic stimulation
Neuroprotective Effect of Brain-Derived Neurotrophic Factor (BDNF) on Cerebral Infarct Volume and Clinical Severity of Acute Ischemic Stroke Satrio Wicaksono; Andi Kurnia Bintang; Muhammad Akbar; Muhammad Yunus Amran; Cahyono Kaelan; Isra Wahid
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 12 No. 1 (2024): Desember
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v12i1.45

Abstract

ABSTRACT Background: Brain-Derived Neurotrophic Factor (BDNF) plays a crucial role in protecting nerves following ischemic stroke. The neuroprotective effects of BDNF on cerebral infarct volume and clinical severity after ischemic stroke need to be further studied in-depth. Purpose(s): The purpose of this study is to understanding the relationship between BDNF levels, cerebral infarct volume, and the severity of clinical conditions in acute ischemic stroke patients. Methods: This study is an observational nalytical research with a cross-sectional design. A total of 30 individuals who meet the inclusion criteria were included as samples. Cerebral infarct volume was measured using non-contrast head CT scans with the Broderick formulation, and clinical severity was assessed using the National Institutes of Health Stroke Scale (NIHSS). The collected data were then analyzed using statistical tests. Results: There is a significant relationship between serum BDNF levels and cerebral infarct volume with a p-value of 0.004 and a correlation coefficient (r) of -0.509. Similarly, a significant relationship exists between serum BDNF levels and NIHSS with a p-value of 0.042 and a correlation coefficient (r) of -0.374. Conclusion: There is a negative correlation between serum BDNF levels and cerebral infarct volume in acute ischemic stroke patients, as well as a negative correlation between serum BDNF levels and clinical severity in acute ischemic stroke patients. Keywords: BDNF; Infarct Cerebri Volume; NIHSS
Co-Authors Cahyono Kaelan David Gunawan Umbas Isra Wahid Jumraini Tammasse Muhammad Akbar Muhammad Yunus Amran Rina Masadah Satrio Wicaksono Ulima Rahma Asri