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All Journal MEDULA Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Medical Community Dedication
Musyarrafah
Universitas Islam Al-Azhar
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Advanced Glycation End-Product (AGEs)Level in a Diabetic Rat Model Treated with Warfarin Anticoagulant Musyarrafah; Halia Wanadiatri; I G.A. Adnyana
MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo Vol. 11 No. 1 (2023): Akhir
Publisher : MEDULA: Jurnal Ilmiah Fakultas Kedokteran Universitas Halu Oleo

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Abstract

Background: Diabetes mellitus is a chronic disease that is the most seriously cause of macrovascular and microvascular complications that threaten life , expensive and reduces life expectancy. The occurence of cell damage and inflammation due to AGEs and RAGE reactions generally exacerbates the risk of macrovascular complications . Pharmacological therapy given to prevent these complications is the warfarin anticoagulant . the duration of warfarin use can increase the hardening of blood vessels or vascular calcification and is compounded by AGEs accumulation and RAGE activation. Objective: To analyze plasma AGE levels as a risk factor for vascular calcification in DM and non-DM rats models treated with warfarin anticoagulants. Method: This study used a Quasi experimental method with a posttest only control group design. The total sample was 28 samples divided into 4 groups, each group consisting of 7 rats grouped into DM + Aquadest group, DM + Warfarin group, non-DM + Aquadest group , and non-DM + Warfarin group. Plasma AGE levels were measured using the ELISA method and the results were analyzed using Anova. Results: AGE Level in the DM + Warfarin group (Mean= 1.183; SD=0.16) was slightly high than AGE level in normal rat group with Warfarin induction (Mean=1,012; SD=0,02). In the normal rat group treated with Aquadest was slightly low than AGE level in the DM rat group with warfarin induction (Mean=1.147; SD=0.13). Interestingly, There was no difference in plasma AGE levels between groups (p=0,155). Conclusion: AGE levels at the onset of DM are not yet able to progressively activate vascular damage through the AGE/RAGE signaling pathway.
Edukasi SEGAR untuk Pencegahan ISPA di Rusunawa Selagalas Mataram Musyarrafah; Sahrun
Medical Community Dedication Vol 1 No 2 (2025): Desember 2025
Publisher : Fakultas Kedokteran Universitas Islam Al-Azhar Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36679/jmcd.v1i2.10

Abstract

Acute Respiratory Infection (ARI) is a major health issue in Rusunawa Selagalas, driven by inadequate ventilation and smoking behavior. The objective of this community service, to identify priority health problems, analyze major risk factors, and implement an educational intervention (“SEGAR”) to reduce ARI risk. Community diagnosis was conducted through direct observation, structured questionnaires (n=91), and priority setting using the Delbecq method with resident participation. Main variables included ventilation, smoking, and ARI incidence. Descriptive (univariate) analysis was performed. ARI was reported in 80.22% of residents, with poor ventilation and smoking as dominant risk factors. The SEGAR education program improved awareness of ventilation hygiene and smoking hazards. Community-based education combined with basic housing improvements is effective in mitigating ARI risk in dense housing. Sustained collaboration between residents, housing managers, and local government is recommended.
Co-Authors I G.A. Adnyana Sahrun Wanadiatri, Halia