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All Journal Journal of Health Innovation and Environmental Education Journal of Academic Biology and Biology Education
Junhong Kim
Pohang University of Science and Technology (POSTECH)
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Public Health Veterinary Other

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Development and Validation of an Integrated Electronic Patient Progress Note-Based Healthcare Evaluation Instrument for Diabetes Management István Fedor; Taisia Chertenko; Junhong Kim
Journal of Health Innovation and Environmental Education Vol. 3 No. 1 (2026): June (On Going)
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jhiee.v3i1.2671

Abstract

Purpose of the study: This research sought to design and rigorously evaluate an Integrated Electronic Progress Note instrument intended to support frailty risk monitoring and strengthen care coordination among older adults. Methodology: A methodological research approach was undertaken, beginning with conceptual framework development and item generation, followed by expert review for content adequacy and empirical validation. Data were obtained from 210 healthcare professionals alongside 320 de-identified electronic progress notes collected at Uzsoki Street Hospital. Psychometric evaluation included content validity indexing, internal consistency assessment, and construct validation using Partial Least Squares Structural Equation Modeling with bootstrapping procedures to test structural relationships. Main Findings: The developed instrument demonstrated high content agreement among experts (S-CVI = 0.93) and strong reliability indicators, with composite reliability values exceeding 0.90. Convergent validity met recommended thresholds (AVE > 0.50), while discriminant validity was confirmed through HTMT ratios below 0.90. The structural analysis indicated that the model accounted for 68% of the variance in documentation quality (R² = 0.68) and showed meaningful predictive capability (Q² = 0.49). Among the examined constructs, Care Coordination exerted the most substantial positive influence on documentation quality (β = 0.41, p < 0.001). Furthermore, improved documentation performance was significantly linked to a lower likelihood of 30-day readmission (β = –0.32, p < 0.01). Novelty/Originality of this study: This study presents a validated multidimensional measurement tool that connects frailty risk assessment elements with the quality evaluation of electronic clinical documentation, thereby advancing the integration of geriatric clinical assessment and digital health governance frameworks.
Molecular Docking-Based in Silico Evaluation of Leaf Compounds from Coleus blumei Against MRSA Pongpawan Sethanant; Junhong Kim; Maurizio Martin Cavani Brain
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1660

Abstract

Purpose of the study: This study aims to investigate the potential of compounds derived from medicinal plants as target protein inhibitors against methicillin-resistant Staphylococcus aureus (MRSA) using an in silico approach. Methodology: This study employed an in silico molecular docking approach to evaluate active compounds from Coleus blumei leaves against MRSA. Target proteins included MecR1, PBP2a, and oxacilloyl-acylated MecR1. Docking was performed using PyRx, PyMOL, and Discovery Studio with molecular data sourced from GC-MS, PubChem, and PDB. Main Findings: The compound Hexahydro-3H-cyclopenta[a]pentalen-3-one, 2,4a,5,6,7,8-hexahydro-4,4,7a-trimethyl-, (4aR,7R,7aS) demonstrated the highest binding affinity across all three MRSA resistance-associated target proteins (PBP2a, MecR1, and oxacillin-acylated MecR1), surpassing penicillin as the control. Molecular interaction visualizations revealed stable hydrogen bonding and hydrophobic interactions with key active site residues, particularly SER, LEU, and PHE in PBP2a. Pharmacokinetic evaluation based on Lipinski's Rule of Five indicated that top-performing compounds, including this compound and Aristolone, exhibit favorable oral drug-like properties. These findings highlight the strong potential of these natural compounds as lead candidates for the development of antibacterial agents targeting MRSA resistance mechanisms. Novelty/Originality of this study: The novelty of this study lies in the utilization of specific natural compounds as potential antimicrobial agents against antibiotic resistance proteins, which have not been widely reported before. This study provides an initial basis for the development of herbal antimicrobial drug candidates for MRSA infections.
Co-Authors István Fedor Maurizio Martin Cavani Brain Pongpawan Sethanant Taisia Chertenko