Sarni
Polytechnic Baubau. Jl. Lakarambau, Lipu, Kec. Betoambari, Kota Bau-Bau, Sulawesi Tenggara 93724, Indonesia

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Formulation and Physical Stability Test of Body Scrub Cream with Mangosteen Peel Extract (Garcinia Mangostana L) Yumiyati; Ratih Nurwanti; Sarni
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1563

Abstract

Background: Mangosteen (Garcinia mangostana L.) is a plant known for its various beneficial properties, particularly in its thick skin, which contains xanthone compounds. These compounds have antioxidant properties that are beneficial for the skin. The use of mangosteen skin extract as a key ingredient in body scrub creams has gained attention due to its potential skin benefits. Objectives: This study aimed to develop a body scrub cream formulation using mangosteen skin extract (Garcinia mangostana L.), assess the physical stability of the cream, and determine the most optimal formulation for its preparation. Methods: This study employed a laboratory experimental design, utilizing a maceration extraction method with 96% ethanol as the solvent to extract mangosteen skin compounds. Three different body scrub cream formulations were prepared with varying concentrations of mangosteen skin extract: Formula 1 (5%), Formula 2 (10%), and Formula 3 (15%). The physical stability and effectiveness of each formulation were tested through organoleptic evaluation, homogeneity, pH, adhesion, spreadability, and cream stability tests. Results: All three body scrub cream formulas were successfully formulated with mangosteen skin extract. However, none of the formulations met the optimal criteria. While all formulas passed the physical stability tests, including organoleptic evaluation, homogeneity, pH, adhesion, and cream consistency, none of the formulas passed the spreadability test. Conclusion: Although the body scrub creams demonstrated acceptable physical characteristics, the spreadability aspect requires further improvement to meet the expected standards for an optimal product. The results indicate the potential of mangosteen skin extract in body scrub formulations, but refinements are necessary to enhance the overall quality. Keywords: Body Scrub Cream, Mangosteen Peel, Phycal Stability Test
Assessment of the Analgesic Effect of Ethanol Extract of Red Lemongrass Leaves (Cymbopogon nardus) Using a Mouse Model (Mus musculus) Findi Prasetia; Muhammad Tasjiddin Teheni; Sarni
Journal of Health Science and Pharmacy Vol. 3 No. 1 (2026): January - April
Publisher : Yayasan Cipta Anak Bangsa (YCAB) Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/jhsp.v3i1.1564

Abstract

Background: Public interest in plant-based traditional medicines continues to increase, encouraging scientific evaluation of commonly used herbal materials, including red lemongrass (Cymbopogon nardus) leaves, which are presumed to possess analgesic properties. Objectives: This study aimed to evaluate the analgesic effectiveness of the ethanol extract of red lemongrass leaves (Cymbopogon nardus) in mice (Mus musculus). Methods: An in vivo experimental design was employed using mice as the test model. Analgesic activity was assessed by quantifying the number of writhing responses (wriggles) following pain induction. The extract was administered in three dose groups, and the data were analyzed using one-way ANOVA to determine differences among groups. Results: The ethanol extract of red lemongrass leaves demonstrated analgesic activity in mice, indicated by a reduction in writhing responses. The highest analgesic effect was observed at a dose of 800 mg/kg body weight, suggesting a dose-dependent relationship in which higher extract doses produced greater analgesic activity. One-way ANOVA showed a significant difference among the extract-treated groups (F = 2.434 > Fcrit = 2.067), leading to rejection of the null hypothesis and confirming statistically significant variation across doses. Conclusion: Ethanol extract of red lemongrass leaves (Cymbopogon nardus) exhibits analgesic effects in mice (Mus musculus), with the most effective dose in this study being 800 mg/kg body weight. The findings support a dose-dependent analgesic response and indicate the potential of C. nardus as a candidate for further analgesic development. Keywords: Cymbopogon nardus; ethanol extract; analgesic activity; writhing test; Mus musculus