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Intan Adevia Rosnarita
Universitas Muhammadiyah Kudus, Kudus, Indonesia
Health Professions

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Evaluation of Antituberculosis Therapy In HIV/AIDS Patients at X Hospital Kudus Elsa Latifatul Luthfi; Endang Setyowati; Intan Adevia Rosnarita
Advances in Healthcare Research Vol. 4 No. 1 (2026): September - February
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v4i1.707

Abstract

Purpose: This study aimed to evaluate the use of antituberculosis drugs (OAT) in HIV/AIDS patients with tuberculosis coinfection at X Hospital in Kudus by identifying patient characteristics, patterns of OAT and antiretroviral (ARV) use, and the rationality of OAT therapy using the Gyssens method. Research Method: This study used a descriptive evaluative design with a retrospective approach based on medical record data. The sample consisted of 41 HIV/AIDS patients with TB coinfection treated at X Hospital in Kudus during November 2024-November 2025, selected using total sampling. Data were analyzed univariately, while therapeutic rationality was assessed using the Gyssens method. Results and Discussion: Most patients were adults (92.7%) and male (82.9%). The most common OAT regimen was RHZE (4FDC) (70.7%), while the dominant ARV regimen was TLD (95.1%). All OATs were administered orally as tablets, and the duration of therapy was appropriate in all cases. The Gyssens evaluation showed rational OAT use in 95.1% of patients and irrational use in 4.9%, with inappropriate dosage as the main problem. Implications: These findings indicate that OAT prescribing practices were generally consistent with treatment guidelines, but body-weight-based dose adjustment still requires improvement. Further studies should explore the relationship between rational therapy, adherence, and clinical outcomes in TB-HIV patients.
Analysis of Patient Satisfaction Levels Toward the Implementation of Electronic Prescribing (E-Prescribing) in the Outpatient Department of Jekulo Kudus Community Health Center Ira Setia Lestari; Endang Setyowati; Intan Adevia Rosnarita
Advances in Healthcare Research Vol. 4 No. 1 (2026): September - February
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v4i1.713

Abstract

Purpose: This study aimed to analyze patient satisfaction with the implementation of electronic prescribing (e-prescribing) in the outpatient department of Jekulo Kudus Community Health Center and to identify the relationship between patient satisfaction and respondent characteristics as well as service-related indicators. It was hypothesized that e-prescribing implementation was associated with a good level of patient satisfaction, although several service attributes still required improvement. Research Method: This study used an analytical observational method with a cross-sectional design involving 96 outpatients. Data were collected using a questionnaire based on five SERVQUAL dimensions: tangibles, reliability, responsiveness, assurance, and empathy. Data analysis included validity and reliability testing, univariate analysis, bivariate analysis using the Mann-Whitney test, and Importance Performance Analysis (IPA). Results and Discussion: Patient satisfaction was significantly associated with age, education level, health insurance status, and frequency of visits to the pharmacy clinic (p < 0.001), while gender, employment status, and number of medications received were not significantly related (p > 0.05). All SERVQUAL dimensions showed high perceived performance scores, indicating generally good satisfaction. However, IPA identified several priority areas for improvement, particularly the clarity of drug information, staff responsiveness, and patient attention. Implications: The findings indicate that e-prescribing has improved outpatient pharmaceutical services, but continuous efforts are needed to strengthen communication and patient-centered interaction. Further studies should explore system efficiency and long-term patient outcomes.
Medication Profile and Side Effect - Severity of Anti-Tuberculosis Drugs in Pulmonary Tuberculosis Patient at Bhina Bhakti Husada Rembang Hospital Nike Sri Wulandari; Endang Setyowati; Intan Adevia Rosnarita
Advances in Healthcare Research Vol. 4 No. 1 (2026): September - February
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v4i1.714

Abstract

Purpose: This study aimed to identify the treatment profile and the type and severity of anti-tuberculosis drug (OAT) side effects in pulmonary tuberculosis patients at Bhina Bhakti Husada Rembang Hospital. It was hypothesized that most patients would receive first-line OAT regimens and experience side effects predominantly of moderate severity. Research Method: This study used a descriptive observational method with a cross-sectional design. Data were obtained retrospectively from the medical records of 106 patients with pulmonary tuberculosis receiving first-line OAT therapy at Bhina Bhakti Husada Rembang Hospital. The variables included patient characteristics, treatment patterns, types of OAT side effects, and severity of adverse drug reactions. Data were analyzed using univariate descriptive analysis. Results and Discussion: Most patients were aged 41-60 years (43.4%), male (64.2%), had a body weight of 30-49 kg (61.3%), and underwent treatment for 1-3 months (42.5%). The most common regimen was category 1 RHZE 2 FDC (39.6%). The most frequent side effects were reddish urine (100.0%), nausea and vomiting (83.0%), and flu syndrome (70.8%). Most side effects were categorized as moderate (56.6%). Implications: The findings emphasize the importance of routine monitoring and early management of OAT side effects, particularly during the early treatment phase. Further studies are needed to examine risk factors associated with severe adverse reactions and their impact on treatment adherence.
Analysis of Patient Characteristics on Potential Drug Interactions in Intensive Care Unit (ICU) Patients at Dr. R Soedjati Purwodadi Grobogan Hospital Eko Retnowati Nabilla; Malika Audrey; Intan Adevia Rosnarita
Advances in Healthcare Research Vol. 4 No. 1 (2026): September - February
Publisher : Yayasan Pendidikan Bukhari Dwi Muslim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60079/ahr.v4i1.737

Abstract

Purpose: This study aimed to analyze patient characteristics associated with potential drug interactions among Intensive Care Unit (ICU) patients at Dr. R Soedjati Purwodadi Grobogan Hospital. It was hypothesized that patient-related factors, particularly the number of prescribed drugs, would influence the occurrence of potential drug interactions. Research Method: This quantitative observational study employed a retrospective cross-sectional design using ICU medical records from January to October 2025. Drug interaction screening was conducted using Medscape and Drug Interaction Checker. The variables included age, sex, comorbidities, number of drugs, interaction severity, and interaction mechanism. Data were analyzed using univariate and bivariate analysis. Results and Discussion: A total of 255 potential drug interactions were identified, with most classified as moderate (56.9%) and pharmacodynamic (62.7%). Most patients were elderly, female, and had comorbidities. Statistical analysis showed no significant relationship between age, sex, or disease history and potential drug interactions, whereas the number of drugs prescribed was significantly associated with interaction occurrence (p < 0.001). Implications: These findings emphasize that polypharmacy is the main determinant of potential drug interactions in ICU patients. Strengthened clinical monitoring, prescription review, and pharmacist involvement are needed to improve medication safety in intensive care settings.
Co-Authors Eko Retnowati Nabilla Elsa Latifatul Luthfi Endang Setyowati Ira Setia Lestari Malika Audrey Nike Sri Wulandari