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Effectiveness of Health Education and Short Message Service Reminders Reminders on Iron Supplement Adherence among Pregnant Women Nare Karapetyan; Lilit Toyonan; Michelle Steenvoorden; Nour Albahri
Journal of Health Innovation and Environmental Education Vol. 3 No. 1 (2026): June (On Going)
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jhiee.v3i1.2672

Abstract

Purpose of the study: This study aimed to evaluate effectiveness structured health professional led education embedded within routine antenatal care in enhancing iron supplement adherence among pregnant women. Methodology: A quasi-experimental pretest–posttest control group design conducted among 120 pregnant women at Masis Maternity Hospital. Participants allocated to intervention group. receiving structured professional-led education with reinforcement or a control group receiving routine care. Primary outcome was iron supplement adherence (≥80% consumption), while secondary outcomes included knowledge score and hemoglobin level changes over 8 weeks. Data analyzed using chi-square tests, independent and paired t-tests, and logistic regression. Main Findings: After 8 weeks, adherence significantly increased to 81.0% in .intervention group compared with 51.7% in control group (p < 0.001). The intervention group was nearly five times more likely to achieve adequate adherence (AOR = 4.83; 95% CI: 2.01–11.61). Knowledge scores improved by +5.27 points in the intervention group versus +1.78 in controls (p < 0.001). Hemoglobin levels increased by 0.86 g/dL in intervention group icompared to 0.32 g/dL control group (p < 0.001). Novelty/Originality of this study: This study advances maternal health practice by reframing health education as a structured, professionally embedded care model rather than a single counseling encounter, demonstrating measurable behavioral and clinical impact within routine antenatal services.
Evaluation of Curcumin as NF-κB Inhibitor for Breast Cancer Therapy Using in Silico Approach Endang Adillah; Nour Albahri; Shrouk Ekramy
Journal of Academic Biology and Biology Education Vol. 2 No. 1 (2025): June
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/jouabe.v2i1.1947

Abstract

Purpose of the study: This study aims to evaluate the potential of curcumin as a breast cancer therapeutic agent by analyzing its ability to inhibit NF-κB activation using an in silico approach, specifically through molecular docking to assess absorption and interaction with the target protein. Methodology: This study used a quantitative experimental method with molecular docking as an in silico approach. Tools included a Lenovo laptop (Intel® Inside™, Windows 10 Pro). Software used: PyRx 0.8 (with AutoDock Vina), YASARA, PyMOL, and Discovery Studio 2019. Ligand data were obtained from PubChem; protein from Protein Data Bank. Lipinski’s Rule was applied for drug-likeness screening. Main Findings: Curcumin showed a binding affinity of -6.2 kcal/mol to NF-κB with RMSD < 2.00 Å. Visualization confirmed hydrogen bonds at ASN 32 and ASN 47, and hydrophobic pi-alkyl interactions at ALA 34 and ARG 50. Lipinski’s Rule of Five was fulfilled, indicating good oral drug-likeness and potential as an NF-κB inhibitor in breast cancer therapy. Novelty/Originality of this study: This study offers new insights into the potential of curcumin as a natural NF-κB inhibitor for breast cancer therapy through a comprehensive in silico approach. By combining molecular docking, visualization, and drug-likeness analysis, it advances current knowledge by highlighting curcumin’s binding efficiency and pharmacological feasibility, supporting its development as an alternative anticancer candidate.