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All Journal Eduvest - Journal of Universal Studies Jurnal Ilmiah Kesehatan Sandi Husada (JIKSH)
Mellyna Mellyna
Master Of Biomedical Science Study Program, Postgraduate Faculty, Universitas Yarsi, Central Jakarta, DKI Jakarta
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Potential of Jatropha Multifida L.- Placenta - Carboxymehyl Chitosan (CMC) Formulation as Regenerative Therapy for Burn Wounds Mellyna Mellyna; Juniarti Juniarti; Nunung Ainur Rahmah
Eduvest - Journal of Universal Studies Vol. 6 No. 4 (2026): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v6i4.52546

Abstract

Second-degree burns are tissue injuries that often cause complications and require a long healing time. Previous studies have reported that natural ingredients such as Jatropha multifida L., placenta extract, and Carboxymethyl Chitosan (JM-P-CMC) have the potential to accelerate tissue regeneration, but no combined studies have been conducted on the three. The study aimed to evaluate the effect of the Jatropha multifida L.-Plasenta-CMC combination formulation on the number of fibroblasts as an indicator of tissue regeneration in second-degree burns. This experimental study used a post-test only control group design with 24 male Sprague dawley rats (200–250 g) induced burns on the back using a hot metal plate, then divided into four groups: control (Bioplacenton ® ), JM5%-P-CMC, JM10%-P-CMC, and JM15%-P-CMC. Topical treatment was carried out twice a day for 14 days. Data collection was carried out on days 5, 9, and 14, followed by histological analysis of skin tissue with Hematoxylin Eosin staining to count the number of fibroblasts. The results of the Kruskal-Wallis and Mann-Whitney tests showed a significant increase in the number of fibroblasts in all treatment groups compared to the control, with the highest results in the JM15%-P-CMC group. This study concluded that the combination was effective in enhancing tissue regeneration and has the potential to be developed as an innovative topical therapy based on natural ingredients.
Effect of jatropha-placenta-cmc formulation on second-degree burn wound healing in rats: Fibroblast growth factor expression Mellyna Mellyna; Juniarti Juniarti; Nunung Ainur Rahmah; Restu Syamsul Hadi; Nabila Pyrenina Thamrin
Jurnal Ilmiah Kesehatan Sandi Husada Vol. 15 No. 2 (2026): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : LPPM Politeknik Sandi Karsa, South Sulawesi, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiksh.v15i2.380

Abstract

Introduction: Second-degree burns require effective topical therapy to accelerate tissue regeneration and reduce complications. Current treatments remain limited by side effects and suboptimal regenerative outcomes. This study aimed to evaluate the effectiveness of a combination gel of Jatropha multifida L. latex, placenta extract, and carboxymethyl chitosan (JM–P–CMC) on burn wound healing by assessing fibroblast growth factor (FGF) expression, fibroblast count, and collagen density. Research Methodology: A post-test-only controlled experimental design was conducted using 18 male Sprague-Dawley rats, allocated into 6 groups. Standardised second-degree burns (1×1 cm) were induced and treated for 15 days. Histological and immunohistochemical analyses were performed at days 5, 10, and 15. Data were analysed using the Kruskal–Wallis and Mann–Whitney tests (α=0.05), with effect sizes expressed as median differences (%) and 95% confidence intervals (CI). Results: The JM–P–CMC group demonstrated significantly higher FGF expression compared to saline (Day 15 median: 75 vs 33; =42%; p=0.0015; 95% CI: 18–60). Fibroblast counts were also significantly increased (median: 55 vs 17; =38%; p=0.0001; 95% CI: 20–64). Collagen density was markedly higher in the intervention group (58.83% vs 21.70%; p<0.01). A strong positive correlation was observed between fibroblast count and collagen density on day 10, whereas FGF showed an inverse regulatory relationship with collagen during the remodelling phase. Conclusion: The JM–P–CMC gel significantly enhances burn wound healing through modulation of FGF expression, fibroblast proliferation, and collagen deposition. This formulation represents a promising, safe, and cost-effective alternative for topical burn management and supports the integration of bioactive-based therapies into clinical and nursing practice.
Co-Authors Juniarti Nabila Pyrenina Thamrin Nunung Ainur Rahmah Nunung Ainur Rahmah Restu Syamsul Hadi