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All Journal Indonesian Journal of Cancer Chemoprevention Global Medical and Health Communication Biology, Medicine, & Natural Product Chemistry Smart Medical Journal Jurnal Kesehatan Vokasional Majalah Sainstekes Medika Alkhairaat : Jurnal Penelitian Kedokteran dan Kesehatan Jurnal Ners Science Midwifery Medicra (Journal of Medical Laboratory Science/Technology) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Junior Medical Journal Eduvest - Journal of Universal Studies Advance Sustainable Science, Engineering and Technology (ASSET)
Nunung Ainur Rahmah
Faculty Of Medicine, Universitas YARSI
Religion Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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The Role of Curcumin on Apoptosis through The RASSF1A and Bax Pathways in Breast Cancer Nunung Ainur Rahmah; Harliansyah Harliansyah; Fransiscus D. Suyatna; Mpu Kanoko; Primariadewi Rustamadji; Joedo Prihartono; Samuel Johny Haryono; Bethy Suryawati Hernowo
Indonesian Journal of Cancer Chemoprevention Vol 11, No 2 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss2pp67-74

Abstract

Curcumin has been reported with an in vitro the cytotoxic effect on several human cancer cells. However, reports on the mode of action and detail mechanism of curcumin in breast cancer disease are limited. Hence, curcumin’s effect on the human breast cancer cell line MCF-7 and MDA-MB-468 was investigated. The MCF-7 and MDA-MB-468 breast cancer cells line were given curcumin in several doses. The anti-proliferation activity of curcumin was determined using the MTS cell viability test and caspase-3 activity was used to detect apoptosis using flowcytometry. The expression of Ras-association domain family 1 isoform A (RASSF1A) and Bax protein in cells was evaluated by ELISA analysis. Kruskal-Wallis followed by the Mann-Whitney test and the Spearman correlation tests were used to asses correlation among RASSF1A, Bax, and caspase-3. Cytotoxicity of curcumin on MCF-7 was lower than that of MDA-MB-468 (75.73 μg/mL and 380.79 μg/mL). The concentration of curcumin at 80 μg/mL induced apoptosis mainly through the intrinsic pathway by caspase-3 activation. Curcumin also showed an anti-proliferative activity as shown by the increase of RASSF1A and Bax protein. Curcumin mediates anti-proliferative and apoptotic effect through the activation of RASSF1A and Bax. Our research data adds information about the role of curcumin in epigenetic events through RASSF1A protein.Keywords: Bax, caspase-3, curcumin, MCF-7, MDA-MB-468, RASSF1A
α-Mangosteen as An Oxidative Inhibitor in Hepatocellular Carcinoma Harliansyah Harliansyah; Nunung Ainur Rahmah; Kuslestari Kuslestari
Indonesian Journal of Cancer Chemoprevention Vol 12, No 2 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss2pp106-113

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and the second leading cause of cancer mortality worldwide. Many strategies to discover molecular-based therapy are currently being implemented to overcome the resistance in HCC treatment. Cancer research is more targeted at molecular level of natural ingredients treatment as chemoprevention to reduce carcinogenesis risk. One of the natural compounds that serve as chemopreventive agent is mangosteen. α-Mangosteen, a xanthone commonly found in the fruit hull of Garcinia mangostana Linn, possess as an antioxidant. This study aims to determine the levels of reactive oxygen species (ROS), malondialdehyde (MDA), and protein carbonyl (PC) as the biomarkers of oxidative stress on untreated HepG2 cells compared to α-mangosteen-treated HepG2 cells. The results indicated that α-mangosteen has a cytotoxic effect on HepG2 cells with IC50=242.58 μg/mL and reduced ROS level 23.15±4.29% at 200 μg/mL. The MDA level of HepG2 cells was not significantly higher than on WRL-68 by 7.6%, 17.93%, 28.8%, 35.32%, and 61.95% at 100, 200, 500, 800, and 1000 μg/mL respectively. α-Mangosteen at 100 and 200 μg/mL reduced protein carbonyl by 76.24 and 79.84% in HepG2 cells line while compared to normal liver cells line (WRL-68) significantly (P<0.05). In conclusion, α-mangosteen reduced levels of ROS, MDA and PC. Therefore, α-mangosteen is a potential anti-cancer agent through oxidative stress inhibition.Keyword: free radical, HepG2 cells, α-mangosteen, oxidative stress.
Perbedaan Morfologi Kelenjar Mammae Dan Jaringan Ikat Pada Kanker Payudara Dan Fibrokistik Di Rumah Sakit Islam Jakarta Triana Intan Sari; Saffa Hasanah; Muhammad Arsyad; Nunung Ainur Rahmah; Yulia Suciati
Majalah Sainstekes Vol 9, No 1 (2022): JUNI 2022
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1011.722 KB) | DOI: 10.33476/ms.v9i1.2650

Abstract

Kanker payudara adalah keganasan yang berasal dari epitel duktus maupun lobules di jaringan payudara. Di sisi lain, penyakit fibrokistik adalah benjolan teraba di payudara dan terkait dengan siklus menstruasi. Karena gejala awal yang mirip, pada pemeriksaan klinis, penyakit fibrokistik sering salah didiagnosis sebagai kanker payudara. Oleh karena tingginya kasus kanker payudara di Indonesia, penentuan stadium klinis dan pemeriksaan histopatologi diperlukan untuk menentukan diagnosis dan tata laksana lebih lanjut.Penelitian ini bertujuan untuk mengetahui bagaimana perbedaan kepadatan jaringan ikat dan perbedaan luas sel pada kanker payudara dan penyakit fibrokistik.Jenis penelitian ini adalah eksperimen dengan rancangan penelitian cross sectional. Sampel dalam penelitian ini adalah blok paraffin pasien kanker payudara dan penyakit fibrokistik di Rumah Sakit Islam Cempaka Putih Jakarta. Pengumpulan data ini dilakukan dengan data primer sediaan biopsi eksisi atau mastektomi pasien kanker payudara dan penyakit fibrokistik dan diolah menjadi sediaan slide menggunakan pewarnaan masson’s trichrome dan Hematoxylin Eosin. Analisis dilakukan menggunakan uji komparatif dua sampel yang tidak berpasangan dan distribusi tidak normal dengan uji Kolmogorov Smirnov.Penelitian ini menunjukkan bahwa rerata luas morfologi kelenjar pada kanker payudara lebih besar dibandingkan penyakit fibrokistik (226,324 um : 60,522 um). Berdasarkan hasil uji analisis didapatkan perbedaan yang bermakna secara statistik antara luas morfologi kelenjar pada kanker payudara dan penyakit fibrokistik. Semenetara jumlah jaringan ikat pada fibrokistik lebih banyak dibandingkan kanker invasif payudara. Kepadatan rata-rata jaringan ikat pada fibrokistik payudara sebesar 52%. Sedangkan kepadatan rata-rata jaringan ikat pada kanker payudara sebesar 29,17%. Berdasarkan hasil uji analisis Kolmogorov Smirnov didapatkan hasil yang signifikan secara statistik antara variabel kepadatan jaringan ikat pada kanker payudara dan penyakit fibrokistik (p kurang dari 0.05).Terdapat perbedaan bermakna jaringan ikat antara kanker payudara dengan penyakit fibrokistik. Sementara luas morfologi kelenjar pada kanker payudara lebih besar dibandingkan penyakit fibrokistik
Clinical Manifestation and Diagnosis of Cryptosporidiosis in Adult Infected with HIV Nunung Ainur Rahmah; Ening Krisnuhoni; Ari Fahrial Syam
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, ISSUE 3, December 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/43200396-99

Abstract

Cryptosporidiosis is a rare infection caused by a coccidian parasite, Cryptosporidium, which could cause diarrhea in humans, especially those who are immunocompromised Cryptosporidiosis could cause self- limited diarrhea infection in immunocompetent hosts, but in immunocompromised hosts, especially those with AIDS, the diarrhea can be chronic and severe. To date, no known effective therapeutic agents have been identified. The following is one case report of cryptosporidiosis of a 27 year-old male admitted with chronic diarrhea since 2 months. Endoscopy of the ileum and colon showed hyperemia, erosion and edema, and biopsy was performed. Histopathological examination of ileum showed an atrophic villous and atypical degeneration. There was a number of circular cryptosporidium lining up along the surface of epithelium. There was inflammatory cell infiltration, consisting of lymphocytes, eosinophils and a few neutrophils in the lamina propria. Serological examination revealed an HIV-positive result. Keywords: Cryptosporidiosis, HIV, diarrhea
Hepatocellular Carcinoma in an Infant due to HBV Vertical Transmission Nunung Ainur Rahmah; Wirasmi Marwoto; Vera Yuwono; Ening Krisnuhoni; Diah Rini Handjari; Darmawan Kartono; David Handojo Muljono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 1, April 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/101200929-32

Abstract

Hepatocellular carcinoma (HCC) is one of the common tumors in the world. The incidence of HCC generally increases with age in all population but there is a tendency of decreasing incidence in the elderly and it is very rare in children. This is a case report of HCC in a 9-month-old boy, who was admitted to the hospital with palpable abdominal mass in the right upper quadrant. Imaging modality by ultrasonography could not adequately demonstrate definite findings demonstrating that the tumor was derived from liver, and the diagnosis was neuroblastoma. Intra-operatively, the tumor mass appeared to be derived from the surface of the posterior edge of the liver, so it was a pedunculated tumor. The histopathological examination revealed a pedunculatedhepatocellular carcinoma grade 3. The Victorian blue staining and immunohistochemical staining were done afterward, which showed HBsAg positive result as found in non-tumor lesion as well as inneoplastic lesion of liver tissue.Keywords: hepatocellular carcinoma, pedunculated HCC, infant HCC, occult hepatitis B virus infection
The Relationship of Anxiety Level with Osce Graduation on Students of The Faculty of Medicine YARSI University Class 2019 and 2020, and The Review According to Islamic Perspective Muhammad Kholik Sanaba; Nunung Ainur Rahmah; Firman Arifandi
Junior Medical Journal Vol 1, No 1 (2022)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (312.958 KB) | DOI: 10.33476/jmj.v1i1.2684

Abstract

Background: Anxiety is a condition that causes changes in a person's emotional atmosphere that can affect students' cognitive function when facing the Objective Structured Clinical Examination and affect student performance. According to the Qur'an, anxiety is explained by the phrase kha?f, which is a condition of unease about the future. This is caused by doubts in the heart or daiq so that hal?'a or anxiety occurs and results in feelings of suffering or hazn. The purpose of this study was to determine the relationship between anxiety levels with online and offline OSCE graduation, age, sex and identify the level of anxiety in YARSI University Faculty of Medicine Students Class of 2019 and 2020.Methods: This type of research is descriptive analytic with a cross sectional research design. The questionnaire was distributed via google form. This research was conducted on students of the Faculty of Medicine, YARSI University batch 2019 and 2020 with a total sample of 209 respondents. Data analysis using Kruskal Wallis test and Kolmogorov-Smirnov test.Results: Based on the results of statistical tests, there is no relationship between anxiety levels with sex, age, and online and offline OSCE graduation in YARSI University Faculty of Medicine Students Class of 2019 and 2020. The level of anxiety experienced by most students is a mild level of anxiety.Conclusion: There are no significant results between the level of anxiety with sex, age, and online and offline OSCE graduation.
Hubungan Pembelajaran Keterampilan Klinis Secara Online dengan Kelulusan OSCE Pada Mahasiswa Angkatan 2019 Fakultas Kedokteran Universitas YARSI Serta Tinjauan Dalam Islam Fitria Nur Ain; Nunung Ainur Rahmah; Firman Arifandi; Aan Royhan
Junior Medical Journal Vol 1, No 5 (2023)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v1i5.3108

Abstract

Latar belakang: Keterampilan klinis adalah metode pembelajaran atau model pembelajaran untuk melatih pengetahuan (kognitif), sikap (afektif) dan keterampilan (psikomotor) melalui pemanfaatan fasilitas laboratorium yang dapat dilakukan secara online untuk mengurangi penyebaran penyakit COVID-19 yang dapat dinilai dengan Objective Structured Clinical Examination. Menurut pandangan islam, belajar merupakan sebuah kewajiban bagi setiap manusia, karena dengan media online manusia bisa meningkatkan kemampuan dirinya. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pembelajaran keterampilan klinis secara online, usia, dan jenis kelamin dengan kelulusan OSCE online dan offline serta tinjauan dalam Islam. Metode: Jenis penelitian berupa deskriptif analitik dengan desain penelitian cross sectional. Kuesioner didistribusikan melalui google form. Penelitian ini dilakukan pada Mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019 dengan jumlah sampel sebanyak 145 responden. Analisis data menggunakan uji Kolmogorov-Smirnov. Hasil: Berdasarkan hasil uji statistik tidak terdapat hubungan yang bermakna antara pembelajaran keterampilan klinis secara online, jenis kelamin, usia dengan kelulusan OSCE online dan offline pada Mahasiswa Angkatan 2019 Fakultas Kedokteran Universitas YARSI. Kesimpulan: Tidak terdapat hubungan antara pembelajaran keterampilan klinis secara online, usia dan jenis kelamin dengan kelulusan OSCE online serta offline.
The Influence of Anxiety Levels Facing Medical Exams to Urinary Incontinence in YARSI University Medical Students Class of 2019 and 2020, and A Review Through Islamic Perspectives Muhammad Achmad Yani; Nunung Ainur Rahmah; Citra Fitri Agustina; Firman Arifandi
Junior Medical Journal Vol 1, No 7 (2023)
Publisher : Junior Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/jmj.v1i7.3206

Abstract

Background: Urinary incontinence is the involuntary excretion of urine at any given condition. Medical exams experienced by medical students could induce anxiety, which could lead to urinary incontinence. Through an Islamic viewpoint, individuals suffering from urinary incontinence are constantly unclean and require certain ways to practice worship. This study aims to determine the relationship between anxiety levels and age; anxiety levels and gender; the correlation between anxiety levels and urinary incontinence; identifying anxiety levels; and the severity of urinary incontinence symptoms within YARSI University Medical Students Class of 2019 and 2020, as well as how to pray and ablute for individuals with urinary incontinence.Method: This study is qualitative research done as an analytical observational study with cross-sectional study design. The research instrument used the Urogenital Distress Inventory questionnaire (UDI-6) and the Hamilton Anxiety Rating Scale (HARS). The research was conducted on YARSI University Medical Students Class of 2019 and 2020 with a sample size of 209 participants. Data analysis utilized Kruskal Wallis, Kolmogorov-Smirnov, and Spearman Correlation statistical tests.Results: The level of anxiety experienced by most students is a mild level of anxiety. The highest severity of urinary incontinence symptoms was experienced by students with moderate to severe anxiety levels. No significant relationship was found between age and gender with anxiety levels. There is a positive correlation with moderate strength between the level of anxiety and urinary incontinence.Conclusion: No relationship was found between anxiety levels facing medical exams with age nor gender and a positive correlation with moderate strength was found between anxiety levels medical exams and urinary incontinence within YARSI University Medical Students Class of 2019 and 2020.
Identifikasi Senyawa Kelompok Antosianin dalam Ekstrak Bunga Telang (Clitoria ternatea) dengan menggunakan uHPLC-MS/MS Indranita, Lusy; Ainur Rahmah, Nunung; Juniarti, Juniarti; Abdussalam, Moch
Majalah Sainstekes Vol. 11 No. 1 (2024): JUNI 2024
Publisher : Lembaga Penelitian Universitas YARSI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33476/ms.v11i1.3940

Abstract

Bunga telang (Clitoria ternatea L) merupakan tanaman yang banyak memiliki efek farmakologis yang cukup baik. Tanaman ini memiliki bunga dengan warna ungu yang menarik yang diduga mengandung senyawa kelompok antosianin. Penelitian ini bertujuan mengidentifikasi senyawa kelompok antosianin dalam ekstrak bunga telang dengan menggunakan ultra high performance liquid chromatography – mass spectroscopy/mass spectroscopy (uHPLC-MS/MS). Pengukuran dengan uHPLC-MS/MS dapat diketahui senyawa kelompok antosianin dalam ekstrak telang adalah Delphinidin-3-(6″-p-coumaroyl)-rutinosida, Sianidin 3-(6″-p-coumaroyl)-rutinosida, Delphinidin-3-(cis-p-coumaroyl-glukosida) dan Cyanidin-3-(p -coumaroyl) glukosa. Oleh karena itu, ekstrak bunga telang telah berhasil dibuktikan mengandung senyawa kelompok antosianin.
The Formulation, Evaluation and Physical Stability Test of Aloe Vera (Aloe vera L.) Extract Gel Preparations with the Addition of Sodium Metabisulfite: Formulasi, Evaluasi dan Uji Stabilitas Fisik Sediaan Gel Ekstrak Lidah Buaya (Aloe vera L.) dengan Penambahan Sodium Meta Wiji Purnamasari, Yulia; Juniarti; Rahmah, Nunung Ainur
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 7 No. 1 (2024): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v7i1.1737

Abstract

Aloe vera (Aloe vera L.) is a plant that has many benefits, such as anti-inflammatory, anti-fungal, antibacterial, and moisturizing the skin. Gel preparations are easily contaminated by bacteria and fungi, so it is necessary to consider adding sodium metabisulfite as a preservative. The aim of this research is to prove the effectiveness of using sodium metabisulfite as a preservative for aloe vera extract gel preparations. The aloe vera plant (Aloe vera L.) was extracted using the maceration method for 3x24 hours using methanol solvent. This research used 5% aloe vera (Aloe vera L.) extract, and in the evaluation and stability test used 4 variation formulations using a carbomer base, only gel base (F1), gel base with the addition of sodium metabisulfite (F2), gel base with 5% aloe vera extract (F3), and gel base with 5% aloe vera extract and sodium metabisulfite (F4). The evaluations carried out were organoleptic tests, pH tests, viscosity tests, and ALT (Total Plate Number) tests and AKK (Yeast Mold Number) tests. The physical stability test is carried out for 3-14 days. The extract yield test results obtained were 4.892%. Organoleptic tests on F1, F2, F3 and F4 did not show changes in color, odor and texture, whereas on day 14 changes in color, odor and texture began to occur in the F3 preparation. The pH test showed pH results of 4.67 (F1), 4.9 (F2), 5 (F3) and 5.1 (F4). The viscosity test shows the gel has a viscosity of 2760 cps (F1), 2650 cps (F2), 2590 cps (F3), and 2575 cps (F4). The ALT and AKK tests showed that there was an increase in the value of the F3 preparation. So based on these results it can be concluded that the best gel preparation is F4
Co-Authors Aan Royhan Abdussalam, Moch Adilah Ulinnuha Agung Novianto, Agung Agustin, Rika Alivia Ahmad Randy Ahmad Rusdan Utomo Ahmad Rusdan Utomo Al Ichsan Alfia, Nurul Ari Fahrial Syam Arifandi, Firman Arrahmani, Betharie Cendera Batubara, Lilian Bethy Suryawati Hernowo Chandra Prasetyo Utomo Citra Fitri Agustina Damayanti, Ndaru Andri Darmawan Kartono David Handojo Muljono Dewa Nyoman Murti Adyaksa Dewa Nyoman Murti Adyaksa Diah Rini Handjari Diah Rini Handjari Dianti, Sry Vhina Dinda, Salsabila Chyllia Diniwati Mukhtar Dr. dr. Hj. Diniwati Mukhtar, M. Kes., AIFM Elan Suherlan Elan Suherlan Endang Purwaningsih Endy Muhammad Astiwara Ening Krisnuhoni Fachry Abda El Rahman Firman Arifandi Firman Arifandi Fitria Nur Ain Fransiscus D. Suyatna Hanna Sari Widya Kusuma, Hanna Sari Widya Harliansyah Harliansyah Harliansyah Harliansyah Harliansyah Indra Kusuma INDRA KUSUMA Indranita, Lusy Irfan Syarif, Irfan Irwandi, Nurmayani Janah, Lulu Ah Joedo Prihartono Juniarti Juniarti . Juniarti Juniarti Kiagus Raihan, Kiagus Raihan Kuslestari Kuslestari Ma'sum, Ali Mellyna Mellyna Mpu Kanoko Muhamad Fathurachman Muhamad Fathurachman Muhammad Achmad Yani Muhammad Arsyad Muhammad Kholik Sanaba Mustofa, Muhammad Samsul Nafik, Said Nashuha Insani Nashuha Insani Nenden Lilis Aisyah Neng Suhaeni Neng Suhaeni Patrisha, Milaviza Pendrianto Pendrianto Pendrianto Pendrianto, Pendrianto prastina sari, Putri Agnia Pratiwi, Nike Primariadewi Rustamadji Putra Pangraizan, Farel Raka Auriza Fathaya Ratu Salia Siskowati Restu Syamsul Hadi Riani, Siti Nur Rostiana, Ajeng Nita Saffa Hasanah Samuel Johny Haryono Sri Utami Susi Endrini Susmiarsih, Tripanjiasih Syafruddin A. R. Lelosutan Taslim, Siti Ghadira Inayah Thamrin, Nabila Pyrenina Toto Heriyanto, S.Pd.I., M.Ag Triana Intan Sari Ulisyafitri, Atikah Vera Yuwono WAHYU WIDOWATI Wiji Purnamasari, Yulia Wirasmi Marwoto Wirasmi Marwoto Yulia Suciati Yuniar, Fanni Yusnidar, Amirah