Water leak testing in automotive wheel manufacturing has traditionally relied on manual visual inspection of bubble formation, introducing subjectivity and limiting repeatability in quality assurance processes. This study developed and experimentally validated a real-time leak detection system based on machine vision, directly integrated with an industrial water leak tester platform. A dataset comprising 686 annotated images was constructed from recorded operational testing sequences and partitioned into 80% training and 20% validation subsets. The network was trained for 150 epochs and deployed within an integrated framework incorporating temporal decision logic and automated event logging to ensure deterministic classification under continuous video streaming. Experimental validation was conducted across five scenarios (A–E), including high-leak, low-leak, no-leak, and in-situ operational testing conditions, totaling 100 trials. The aggregated confusion matrix yielded 60 true positives and 40 true negatives with zero false positives and false negatives, resulting in accuracy, sensitivity, specificity, precision, and F1-score values of 1.0 within the evaluated domain. Receiver operating characteristic and precision–recall analyses confirmed strong class separability and stable decision boundaries. Although the results demonstrated high discriminative performance under controlled and operational settings, further large-scale validation under heterogeneous industrial environments is required to fully assess long-term robustness. The proposed framework provided an automated, objective, and real-time inspection solution aligned with Industry 4.0 principles for intelligent manufacturing systems.