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All Journal Cendana Medical Journal
Abatan, Lorenza
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Health Professions Medicine & Pharmacology Public Health

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EFFECT OF SAMBILOTO EXTRACT (Andrographis paniculata Nees ) ON HISTOPATHOLOGICAL DISCUSSION OF WHITE RATS (Rattus norvegicus) HIPERKOLESTEROLEMIA MODELS Abatan, Lorenza; Manafe, Derri Tallo
Cendana Medical Journal Vol 14 No 1 (2026): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v14i1.22318

Abstract

Introduction: Hypercholesterolemia is a state which can increase free radicals in the body. Sambiloto has antioxidant and anti-inflammation effects that will bind with the free radicals. Methods: This research is a laboratory experimental study with the approach of true experimental design post-test with control group applied to the treatment and control group. The sampling technique is using randomized probability sampling. Samples divided into 6 groups consisted of normal control group, negative control group, positive control group and 3 groups of applying the extract in several doses. Results: Bivariate analysis results shows there is a significant effect on sambiloto extract giving with the jejunum histopathological image on wistar strain white rats (Rattus norvegicus) exposed to hypercholesteremia model with the significance value of p= 0,001 (p<0,05). Discussion: Administration of Sambiloto extract at a dose of 800 mg/kgBB has a significant effect in repairing damage to the jejunum of white rats due to hypercholesterolemia. Sambiloto has antidislipidemia, antioxidant and anti-inflammatory effects. Andrographolid increases HDL levels by increasing the activity of lecithin cholesterol acyl transferase (LCAT). Conclusion: There is a significant result on sambiloto extract giving with the jejunum histopathological image on wistar strain white rats (Rattus norvegicus) exposed to hypercholesteremia model.
Co-Authors Deri Riskiyanti Tallo Manafe