This study aims to analyze the determinants of female workers on economic growth in Central Sulawesi Province during the period 2014–2024. Economic growth in this study is measured using the growth rate of Gross Regional Domestic Product (GRDP) per capita as the dependent variable. The independent variables analyzed include female life expectancy, women’s income contribution, and women as professional workers, which represent the dimensions of health, economic contribution, and the quality of women’s participation in the labor market. This study employs a quantitative approach using panel data regression analysis. Model selection was conducted through the Chow test and Hausman test, which indicate that the Fixed Effect Model (FEM) is the most appropriate estimation model. The results show that simultaneously the determinants of female workers influence economic growth in Central Sulawesi Province. However, partially, the variables of female life expectancy, women’s income contribution, and women as professional workers do not show a statistically significant effect on the growth rate of GRDP per capita during the study period. These findings indicate that improvements in women’s welfare indicators and economic participation have not yet been fully translated into improvements in regional economic performance. Therefore, more gender-responsive development policies are required, including strengthening the quality of women’s human capital, expanding access to education and professional training, and increasing employment opportunities in high value-added economic sectors in order to promote more inclusive and sustainable economic growth in Central Sulawesi Province.