<![CDATA[Diabetes mellitus is a metabolic disease characterized by elevated blood glucose. Untreated hyperglycemia can lead to the production of free radicals and increased oxidative stress, which play a key role in the destruction of pancreatic beta cells and microvascular complications, such as kidney failure. Physalis angulata L. is known to have antihyperglycemic activity and contains antioxidants that have the potential to protect kidney function. This study aims to determine the effect of single administering aqueous extract of ceplukan herb and in combination with metformin on creatinine levels in rat models of kidney failure and diabetes mellitus. The test animals, male Wistar rats, were given renal failure induction treatment using the ischemic reperfusion method and given alloxan 150 mg/kgBW to induce diabetes mellitus and were given a single treatment of ceplukan herb water extract 7 mg/kgBW and a combination of ceplukan herb water extract 3.5 mg/kgBW with metformin 22.5 mg/kgBW given orally for 21 days. The results of the study showed that a single administration of ceplukan herb water extract showed the highest percentage of creatinine inhibition (55.84%) compared to the combination group (50.55%) in rats as animal models of kidney failure and diabetes mellitus. Therefore, it can be concluded that a single administration of ceplukan herb water extract is more effective in reducing creatinine levels in rats as animal models of kidney failure and diabetes mellitus.]]>
