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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Medika Kartika : Jurnal Kedokteran dan Kesehatan Science Midwifery Journal of Food and Pharmaceutical Sciences Inovasi Kesehatan Global Kartika : Jurnal Ilmiah Farmasi Jurnal Farmasi Galenika
Anna Choirunnisa, Anna
Fakultas Farmasi Universitas Jenderal Achmad Yani, Jalan Terusan Jend. Sudirman, Cimahi.
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Water Extract Influence of Stachytarpheta jamaicensis (L.) Vahl Leaves to Prevent Psoriasis Severity in Animal Model Encep Abdurahman; Nengdiana Permana; Grace S. Mardiana; Afifah B. Sutjiatmo; Anna Choirunnisa; Suci N. Vikasari
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 3, No. 1 (2021)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.36335

Abstract

Psoriasis is an autoimmune disease that is characterized by the appearance of lesions on the skin. The current treatment aims to control the symptoms. The efficacy of Stachytarpheta jamaicensis (L.) Vahl’s for autoimmune rheumatoid arthritis and systemic lupus erythematosus has been tested in animal models. The aim of this research was to evaluate the effect of the water extract of S. jamaicensis leaves on psoriasis model animal (male Balb/c mice) induced topically by imiquimod. The water extract of S. jamaicensis leaves is made by boiling. The animal was divided into groups: normal, control, methotrexate 0.2 mg/kgBW, the extract (doses 25, 50 and 100 mg/kgBW). The measured parameters were the Psoriasis Area and Severity Index (PASI) score and skin histopathology. The results showed that all doses of the extract could reduce the PASI score when compared to the control group. Histological results showed that there was a decrease in keratin growth in test animals that were given the extract. Extracts at doses of 25 and 50 mg/kgBW can reduce the thickening of keratin in the epidermis of the back and ears. It can be concluded that the water extract of S. jamaicensis leaf has the most effective activity to prevent psoriasis recurrence in the dose range of 25 and 50 mg/kgBW.Keywords: Psoriasis, Stachytarpheta jamaicensis leaf water extract, PASI, keratin, imiquimod
Antibacterial effects of plants from lembang highland towards skin-infecting microorganisms Anna Choirunnisa; Ita Nur Anisa; Dwi Yuliana Prasita; Suci Nar Vikasari
Science Midwifery Vol 11 No 1 (2023): April: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i1.1198

Abstract

Bacterial skin infection is a common infection in Indonesia. Staphylococcus aureus cause skin and soft tissue infections and Propionibacterium acnes causes acne (acnes vulgaris). Moringa oleifera, Piper betle, and Leucaena leucocephala leaves traditionally use as. This study aims is to evaluate antimicrobial activity of the ethanol extract of the leaves from Lembang highland against S. aureus and P. acnes. The extract of each leaves prepared using reflux in 50% ethanol and examination of antibacterial activity of the ethanol extract using the microdilution method in vitro. The results showed that the ethanol extracts of M.oleifera, P.betle, and L.leucocephala leaves had antibacterial activity against S. aureus and P. acnes with different minimum inhibitory concentrations. The greatest antibacterial activity against S.aureus was shown by the ethanol extract of moringa leaves (MIC = 1024 µg/ml), where the greatest antibacterial activity against P. acnes was possessed by the ethanol extract of betel leaves (MIC = 512 µg/ml).
UJI AKTIVITAS ANTIMIKROBA EKSTRAK ETANOL DAUN KARUK (Piper sarmentosum Roxb.) TERHADAP Streptococcus mutans DAN Candida albicans Vina Septiani; Anna Choirunnisa; Akhirul Kahfi Syam
Kartika : Jurnal Ilmiah Farmasi Vol 5 No 1 (2017)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v5i1.87

Abstract

ABSTRAKPenggunaan antibiotik dengan intensitas yang relatif tinggi menimbulkan berbagai permasalahan dan merupakan ancaman global bagi kesehatan terutama resistensi bakteri terhadap antibiotik. Indonesia yang kaya akan keanekaragaman hayati, menjadi potensi besar bagi pengembangan obat-obatan dari tanaman, termasuk tanaman yang berkhasiat sebagai antimikroba. Salah satu tanaman tersebut adalah karuk  (Piper sarmentosum  Roxb.).  Penelitian  ini  bertujuan  untuk  mengetahui  aktivitas antimikroba dari  ekstrak  etanol  daun  karuk  (Piper  sarmentosum  Roxb.)  terhadap  Streptococcus  mutans  dan Candida  albicans.  Ekstraksi  dilakukan  dengan  metode  maserasi  menggunakan  pelarut  etanol  96%. Pengujian aktivitas antimikroba menggunakan metode difusi agar perforasi dan metode mikrodilusi. Hasil  menunjukkan  dari  3  konsentrasi  ekstrak  uji,  konsentrasi  ekstrak  etanol  daun  karuk  80% menghasilkan diameter hambat terbesar terhadap Streptococcus mutans dan Candida albicans yaitu 19,87 mm dan 15,13 mm. Konsentrasi hambat minimum (KHM) ekstrak etanol daun karuk terhadap Streptococcus  mutans  sebesar  4096  µg/mL,  sedangkan  KHM  tetrasiklin  sebesar  256  µg/mL.  Nilai KHM ekstrak etanol daun  karuk terhadap Candida albicans sebesar 4096 µg/mL, sedangkan KHM ketokonazol sebesar 100 µg/mL.Kata kunci  :  Antimikroba,  Daun  Karuk  (Piper  sarmentosum  Roxb.),  Streptococcus  mutans, Candida albicansABSTRACT The use of antibiotics with relatively high intensity raises variety of problems and is a global threat to health, especially of bacterial resistance to antibiotics. Indonesia is rich in biodiversity, being a huge potential for development of medicines from plants, including plants that are useful as antimicrobials. One  of  that  plants  is  karuk  (Piper  sarmentosum  Roxb.).  The  aim  of  this  research  was  to  study antimicrobial activity of ethanolic extract from karuk leaf against Streptococcus mutans dan Candida albicans. Extraction  was  done  by  maceration  method  using  ethanol  96%  as  solvent.  Antimicrobial activity test was  done  by  agar  diffusion  method  and microdilution  method. The  result  showed  that among 3 concentration of testesd extract,  extract concentrations 80% produce the biggest inhibition diameter 19,87 mm and 15,13 mm. The minimum inhibitory concentration (MIC) of ethanolic extract from  karuk  leaf  against  Streptococcus  mutans  was  4096  µg/mL,  while  MIC  of  tetracycline  was  8 µg/mL. MIC value of ethanolic extract from karuk leaf against Candida albicans was 4096 µg/mL, while MIC of ketokonazole was 100 µg/mL. Keywords  : Antimicrobial,  Karuk  Leaf  (Piper  sarmentosum  Roxb.),  Streptococcus  mutans, Candida albicans
Pengaruh kombinasi ekstrak etanol herba cecendet (Physalis angulata l.) dengan beberapa antibiotik terhadap bakteri Staphylococcus aureus dan Klebsiella pneumonie Anna Choirunnisa; Afifah Bambang Sutjiatmo
Kartika : Jurnal Ilmiah Farmasi Vol 5 No 2 (2017)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v5i2.114

Abstract

The effect of a combination of ethanol extract of Physalis angulata L. with antibiotic against Staphylococcus aureus and Klebsiella pneumonie                                                                                           Abstract Infectious disease is one of the biggest health problems not only in Indonesia, but worldwide. Bacteria are important agents in causing infectious diseases. Indonesian people often use antibiotics along with herbal medicines. Cecendet (Physalis angulata L.) is one of the traditional plants that have antibacterial activity and widely used by the Indonesian community. This study aims to test the antibacterial activity of cecendet herbs and their effects when used in combination with various antibiotics. The preparation of P.angulata extract was carried out using reflux method with ethanol 50%. The characteristic examination and phytochemical screening are examined on simplicia and the extract. Determination of antibacterial activity from P.angulata extract was done by microdilution test method by assessing minimum inhibitory concentration (MIC). Determination of the effectiveness of combination of antibiotics with herbal cecendet against test microbes Staphylococcus aureus and Klebsiella pneumoniae was done by using checkerboard method. The results of phytochemical screening showed that simplicia and P.angulata extract contained alkaloids, flavonoids, saponins, polyphenols, monoterpenoids, sesquiterpenes, steroids and triterpenoids. The result of antibacterial activity test showed that P.angulata extract had antibacterial activity against S.aureus and K.pneumoniae with the MIC was 128 μg/mL, 256 μg/mL. The synergistic interaction of S.aureus is demonstrated by the combination of P.angulata herb extract with tetracycline. The additive/indifferent interaction of S.aureus is demonstrated by the combination of P.angulata extracts with ampicillin, and against K.pneumoniae shown by the combination of P.angulata extract of cecendet with ampicillin or tetracycline. Ethanol extract of P.angulata has antibacterial activity and and combination with antibiotics (ampicillin/tetracyclin) can give synergistic effect or additive of S.aureus and K.pneumoniae bacteria. Keywords:  Cecendet, Physalis angulata L., MIC, antibiotic combination
INTERAKSI EKSTRAK ETANOL DAUN SIRIH HIJAU (Piper betle L.) DENGAN AMOKSISILIN TERHADAP BAKTERI Enterococcus faecalis DAN Streptococcus mutans Choirunnisa, Anna Choirunnisa; Septiani, Vina; Irawan, Nabilla Irania; Widyani, Intan Nuradhariyah
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 2 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rongga mulut merupakan tempat yang paling banyak ditumbuhi mikroorganisme. Contoh penyakit yang disebabkan oleh bakteri adalah infeksi saluran akar yang disebabkan oleh Enterococcus faecalis dan karies gigi yang disebabkan oleh bakteri Streptococcus mutans. Tanaman yang memiliki aktivitas antibakteri dapat digunakan untuk mengobati penyakit infeksi, diantaranya daun sirih hijau (Piper betle L.) yang sudah sejak dahulu digunakan masyarakat sebagai antiseptik. Penggunaan bersama antara antibakteri dengan ekstrak tanaman merupakan salah satu cara baru untuk mengobati penyakit infeksi. Penelitian ini bertujuan untuk mengetahui sifat interaksi yang terjadi saat digunakan bersama antara ekstrak etanol 50% daun sirih hijau dengan antibiotik Amoksisilin. Pembuatan ekstrak etanol daun sirih hijau dilakukan dengan metode refluks, kemudian dilakukan karakteristik simplisia dan penapisan fitokimia. Penentuan Konsentrasi Hambat Minimum (KHM) dilakukan dengan metode mikrodilusi, sedangkan untuk menentukan sifat interaksi digunakan metode papan catur dan pita kertas. Nilai KHM ekstrak etanol 50% daun sirih hijau terhadap bakteri E. faecalis dan S. mutans secara berturut-turut sebesar 16384 µg/ml; 8192 µg/ml. Interaksi antara amoksisilin dengan ekstrak etanol 50% daun sirih hijau menunjukkan sifat yang sinergis. Oleh karena itu, penggunaan bersama antara ekstrak etanol 50% daun sirih hijau dengan amoksisilin memberikan hasil yang lebih baik dibandingkan dengan penggunaan tunggal. Kata kunci: antibakteri, daun sirih hijau, Enterococcus faecalis, infeksi rongga mulut, Streptococcus mutans DOI : 10.35990/mk.v8n2.p118-129
Pengaruh Edukasi terhadap Kepatuhan Siswi Usia Remaja dalam Penggunaan Tablet Tambah Darah Debi Rianti; Suryani Suryani; Anna Choirunnisa
Inovasi Kesehatan Global Vol. 2 No. 1 (2025): Februari : Inovasi Kesehatan Global
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/ikg.v2i1.1364

Abstract

This study aims to examine the effect of education on the adherence of adolescent girls to iron supplementation tablets (IST). Anemia in adolescent girls is a significant health problem, influenced by iron loss during menstruation and increased iron requirements during growth. Low adherence to IST consumption is caused by various factors, including unpleasant side effects after consuming IST, the perception of being healthy and not needing medication, and a lack of knowledge about the dangers of iron deficiency anemia in adolescence. The method used is a narrative review, with research journal sources related to the adherence of adolescent girls in consuming IST. These research journals were obtained from Google Scholar and selected those published in the last five years (2019-2023). The review results indicate the importance of education in increasing adherence to IST consumption. Audiovisual methods, such as videos and YouTube, have proven effective. Additionally, support from health workers and pharmacists is crucial in increasing the adherence of adolescent girls to IST consumption. It is concluded that innovative education and good support are essential in increasing the adherence of adolescent girls to IST consumption.
Pengaruh Ekstrak Air Herba Ceplukan (Physalis angulata L.) Terhadap Kadar Kreatinin Pada Tikus Model Hewan Gagal Ginjal dan Diabetes Melitus R. Lucky Rachmawan; Anna Choirunnisa; Nayla Nazza Rustaman
JURNAL FARMASI GALENIKA Vol 13 No 1 (2026): Jurnal Farmasi Galenika Volume 13 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v13i1.418

Abstract

Diabetes mellitus is a metabolic disease characterized by elevated blood glucose. Untreated hyperglycemia can lead to the production of free radicals and increased oxidative stress, which play a key role in the destruction of pancreatic beta cells and microvascular complications, such as kidney failure. Physalis angulata L. is known to have antihyperglycemic activity and contains antioxidants that have the potential to protect kidney function. This study aims to determine the effect of single administering aqueous extract of ceplukan herb and in combination with metformin on creatinine levels in rat models of kidney failure and diabetes mellitus. The test animals, male Wistar rats, were given renal failure induction treatment using the ischemic reperfusion method and given alloxan 150 mg/kgBW to induce diabetes mellitus and were given a single treatment of ceplukan herb water extract 7 mg/kgBW and a combination of ceplukan herb water extract 3.5 mg/kgBW with metformin 22.5 mg/kgBW given orally for 21 days. The results of the study showed that a single administration of ceplukan herb water extract showed the highest percentage of creatinine inhibition (55.84%) compared to the combination group (50.55%) in rats as animal models of kidney failure and diabetes mellitus. Therefore, it can be concluded that a single administration of ceplukan herb water extract is more effective in reducing creatinine levels in rats as animal models of kidney failure and diabetes mellitus.
In Vitro Anti-Bacterial Activity And Network Pharmacology Analysis of Aqueous Extract of Marsdenia Tinctoria R.Br. Leaves agains Staphylococcus aureus Anna Choirunnisa; Ari Sri Windyaswari; Guntur Berlian; Andrian Rafliana Supriatnaputra; Suryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27290

Abstract

Staphylococcus aureus is a major Gram-positive microorganism implicated in a wide range of skin infections. The increasing prevalence of antimicrobial resistance among S. aureus emphasizes the need for the development of novel therapeutic interventions. This study evaluated the antibacterial efficacy and analysis the molecular mechanism of Marsdenia tinctoria R.Br. (Tarum Areuy) leaf aqueous extract against S. aureus through integrated in vitro and network pharmacology analyzed. The aqueous extract was prepared by infusion, and its metabolite profile was characterized using UPLC-HRMS. Antibacterial activity was quantitatively investigated using the agar well diffusion method against S. aureus ATCC 6538. Network pharmacology identified ten secondary metabolites with antibacterial potential, seven of which exhibited pharmacokinetic properties that met the established bioavailability criteria (BOILED-Egg method). Protein-protein interaction (PPI) analysis indicated that fifteen key proteins interact with the seven compounds, with quercetin identified as the major bioactive compound activating specific bacterial pathways (SAV0081 and pkrC) in S. aureus. The highest antibacterial effect was observed at an 8% extract concentration with an inhibition zone of 17.03 ± 1.78 mm. Overall, these results confirm that the aqueous extract of M. tinctoria leaves contains potential metabolites as antibacterials that could be further developed as therapeutic agents for the treatment of S. aureus infections.
In Vitro Anti-Bacterial Activity And Network Pharmacology Analysis of Aqueous Extract of Marsdenia Tinctoria R.Br. Leaves agains Staphylococcus aureus Anna Choirunnisa; Ari Sri Windyaswari; Guntur Berlian; Andrian Rafliana Supriatnaputra; Suryani
Journal of Food and Pharmaceutical Sciences Vol 14, No 4 (2026): J.Food.Pharm.Sci (In Press)
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.27290

Abstract

Staphylococcus aureus is a major Gram-positive microorganism implicated in a wide range of skin infections. The increasing prevalence of antimicrobial resistance among S. aureus emphasizes the need for the development of novel therapeutic interventions. This study evaluated the antibacterial efficacy and analysis the molecular mechanism of Marsdenia tinctoria R.Br. (Tarum Areuy) leaf aqueous extract against S. aureus through integrated in vitro and network pharmacology analyzed. The aqueous extract was prepared by infusion, and its metabolite profile was characterized using UPLC-HRMS. Antibacterial activity was quantitatively investigated using the agar well diffusion method against S. aureus ATCC 6538. Network pharmacology identified ten secondary metabolites with antibacterial potential, seven of which exhibited pharmacokinetic properties that met the established bioavailability criteria (BOILED-Egg method). Protein-protein interaction (PPI) analysis indicated that fifteen key proteins interact with the seven compounds, with quercetin identified as the major bioactive compound activating specific bacterial pathways (SAV0081 and pkrC) in S. aureus. The highest antibacterial effect was observed at an 8% extract concentration with an inhibition zone of 17.03 ± 1.78 mm. Overall, these results confirm that the aqueous extract of M. tinctoria leaves contains potential metabolites as antibacterials that could be further developed as therapeutic agents for the treatment of S. aureus infections.
Co-Authors Afifah B. Sutjiatmo Afifah Bambang Sutjiatmo, Afifah Bambang Akhirul Kahfi Syam Andrian Rafliana Supriatnaputra Ari Sri Windyaswari Debi Rianti Dwi Yuliana Prasita Encep Abdurahman Grace S. Mardiana Guntur Berlian Irawan, Nabilla Irania Ita Nur Anisa Nayla Nazza Rustaman Nengdiana Permana R. Lucky Rachmawan Septiani, Vina Suci Nar Vikasari, Suci Nar SURYANI Suryani Suryani Sutjiatmo, Afifah Bambang Vina Septiani Vina Septiani, Vina Widyani, Intan Nuradhariyah