A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp.

Murtihapsari Murtihapsari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Papua, Jalan Gunung Salju, Amban, Manokwari, )
Amir M Suruwaky (3Marine and Fishery Polytechnic of Sorong, Sorong 98401, West Papua, Indonesia)
Kadarusman Kadarusman (Marine and Fishery Polytechnic of Sorong, Sorong 98401, West Papua, Indonesia Fishery Higher School, KKP PSP-BIOVASI, Pasar Minggu, Jakarta Selatan 12520, Indonesia)
Dikdik Kurnia (Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Padjadjaran)
Tati Herlina (Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Padjadjaran)
Unang Supratman (Departemen Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Padjadjaran Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Indonesia)

VALENSI
Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018

A new antiplasmodial compound, 2-(3H-diazirine-3-yl)benzaldehyde (1), has been isolated from the Papuan marine sponge Xestospongia sp. The structure elucidation of compound 1 was determined by spectroscopic evidences including UV, IR, MS, 1D and 2D-NMR analysis. Compound 1 showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 value of 1.08 x 10-6 mM. DOI:http://dx.doi.org/10.15408/jkv.v4i1.6735