Gambaran Histopatologi Ginjal Tikus Wistar Diabetes Melitus Eksperimental yang Diberikan Ekstrak Etanol Daun Kelor

Baiq Renny Kamaliani (Praktisi Dokter Hewan di Kota Mataram Lombok, Nusa Tenggara Barat)
Ni Luh Eka Setiasih (Histology Laboratory, Faculty of Veterinary Medicine, Udayana University, Denpasar)
Ida Bagus Oka Winaya (Pathology Laboratory, Faculty of Veterinary Medicine, Udayana University, Denpasar)

Buletin Veteriner Udayana
Vol. 11 No. 1 Pebruari 2019

This study aims to prove that the Moringa leaf extract can improve renal histological structure of diabetic Wistar rats. Wistar rats were divided into six groups, so that each group has four replications. K1 as the positive control was not given the extract, K2 was administered the extract dose 100 mg/kg, K3 was administered the extract dose 200 mg/kg, K4 was administered the extract dose 300 mg/kg, K5 was administered the extract dose 400 mg/kg, K6 was administered the extract dose 500 mg/kg. The administrations of extract were held for five weeks. Rats then sacrificed and the kidneys were taken for the histopathology preparations with Hematoxylin-Eosin staining (HE). The observations indicate fatty degeneration and necrosis of the kidneys. Kruskal Wallis test results of all treatments showed p = 0.001 in both fatty degeneration and necrosis (p <0.05).