THE EFFECT OF CONCENTRATION OF CARRIER, pH AND TIME OF EXTRACTION ON SEPARATION'S FACTOR OF PENICILLIN G - PHENYL ACETATE BY REACTIVE EXTRACTION

Imam Santoso (Department of Chemistry, Faculty of Mathematics and Natural Sciences, State University ofJember, Jember)
Buchari Buchari (Department of Chemistry, Institute Technology of Bandung, Jl Ganesha 10 Bandung)
M. Bachri Amran (Department of Chemistry, Institute Technology of Bandung, Jl Ganesha 10 Bandung)
Aminudin Sulaeman (Department of Chemistry, Institute Technology of Bandung, Jl Ganesha 10 Bandung)

Indonesian Journal of Chemistry
Vol 7, No 2 (2007)

The aim of this research is to study the effect of concentration carrier, pH and time of extraction on separation's factor of penicillin g - phenyl acetate by reactive extraction technique. The 10 mL  aqueous  solution with variation of  pH : 5, 6 contains 0.001 M penicillin G and 0.001 M phenyl acetate has been extracted with 10 mL n-butyl acetate contains dioctylamine as carrier. Variation concentration  of carrier were 0.000; 0.002; 0.004; 0.006 and 0.008 M. Variation time of extraction were 1, 5, 10, 15 and 20 min. The penicillin G and phenyl acetate that dissolved in organic phase ha been  reextracted with 10 mL aqueous with variation of pH : 7, 8. The optimum condition obtained as follow : concentration dioctylamine was 0.002M ; pH the first phase water was 5 and the second phase water was 8 ; and the time of extraction was 10 min.