The objective of this research is to know the effectiveness of Learning Cycle 5E (LC5E) model in basic laws of chemistry material in improving student’s study motivation and concepts mastery. The research class was 23 students of X2 classroom that have an equal academic abilities. This was a pre experiment research using one group pretest-posttest design. Effectiveness of learning with LC5E model was measured based on significant gain improvements. The results showed that average value of N-gainof student’s study motivation in research class were 0,42 respectively; and average value of N-gain for concept mastery in research class was 0,5750 respectively. The hypothesis result test showed that classroom that used LC5E model had higher student’s study motivation and concept mastery than before. This indicated that LC5E model was more effective to improve student’s study motivation and student’s concept mastery at SMA Muhammadiyah I Way Jepara. Keywords: Learning Cycle 5E (LC5E), study motivation, and mastery of concept
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