Biota
Vol 13 No 1 (2020)

Cytotoxicity Assay of 2,4-Dihydroxide-4’-Methoxychalcone Against Cervical (HeLa) Cancer Cell by MTT Assay

Novia Suryani (Unknown)
Sabirin Matsjeh (Unknown)
Mutmainah Mutmainah (Unknown)
Daratu Eviana Kusuma Putri Eviana Kusuma Putri (Unknown)
Damayanti Iskandar (Unknown)
Syarifah Asyura (Unknown)

Article Info

Publish Date
30 Jun 2020

Abstract

Chalcone is one of the phenolic group secondary metabolic with numerous biological activity. Many studies have shown that chalcone derivatives compound has anticancer, anti-inflammatory, antimalarial, and antibacterial activities. The purpose of this research was to study the prediction potency unsaturated carbonyl system of chalcone derivative against the HeLa cell by MTT assay. Those activities assumed can inhibit the mechanism action of NF-kB that caused cervical cancer. The 2,4-dihydroxide-4’-methoxychalcone has done synthesis as a target compound by a sonochemical for 7 hours. The results showed that chalcone derivative most active against the HeLa cell.

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Journal Info
Biota
Website

Abbrev

jb

Publisher

Universitas Islam Negeri Mataram

Subject

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Medicine & Pharmacology

Description

Focus and Scope of Biota on Bioscience, includes: cell biology and genetics, biodiversity, ecology, physiology and biotechnology. Biota covers all life forms, including microbes, fungi, plants, virus, animal and human. Focus and Scope of Biota on Biology Education, includes: Experimental Research, ...