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All Journal Biota SPIN: Jurnal Kimia & Pendidikan Kimia
Novia Suryani
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Medicine & Pharmacology

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Cytotoxicity Assay of 2,4-Dihydroxide-4’-Methoxychalcone Against Cervical (HeLa) Cancer Cell by MTT Assay Novia Suryani; Sabirin Matsjeh; Mutmainah Mutmainah; Daratu Eviana Kusuma Putri Eviana Kusuma Putri; Damayanti Iskandar; Syarifah Asyura
Biota Vol 13 No 1 (2020)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v13i1.235

Abstract

Chalcone is one of the phenolic group secondary metabolic with numerous biological activity. Many studies have shown that chalcone derivatives compound has anticancer, anti-inflammatory, antimalarial, and antibacterial activities. The purpose of this research was to study the prediction potency unsaturated carbonyl system of chalcone derivative against the HeLa cell by MTT assay. Those activities assumed can inhibit the mechanism action of NF-kB that caused cervical cancer. The 2,4-dihydroxide-4’-methoxychalcone has done synthesis as a target compound by a sonochemical for 7 hours. The results showed that chalcone derivative most active against the HeLa cell.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY TEST OF ARA FRUIT EXTRACT (Ficus racemosa Linn.) USING DPPH METHOD Hidayanti, Baiq Rauhil; Novia Suryani; Yuli Kusuma Dewi
SPIN JURNAL KIMIA & PENDIDIKAN KIMIA Vol. 5 No. 2 (2023): Juli - Desember 2023
Publisher : UIN Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/spin.v5i2.7306

Abstract

Ficus racemosa Linn. is a native Indonesian plant known as the ara plant in Lombok or Elo in East Java. The fruit has a fragrant aroma, soft texture, mild sweet taste and a little sour. Presence of ara (Ficus racemosa Linn.) is mostly known as one of the plants whose fruit can only be eaten and used as a medicine for diarrhea, but the compounds contained in ara are not yet known, so research is needed. The purpose of this study was to determine the secondary metabolit content of ara fruit extract and antioxidant activity using the DPPH method. Ara fruit was extracted by maceration method using methanol solvent. The results of the phytochemical screening showed that the ara fruit extract contained secondary metabolites, such as flavonoids, steroids, saponins and tannins. Antioxidant activity (IC50) extract of ara with various concentrations of 25; 50; 75; 100; and 125 ppm soul a value of 65.042 ppm. Based on the results of antioxidant activity, it can be seen that ara fruit extract is classified as a strong antioxidant.
Co-Authors Damayanti Iskandar Daratu Kusuma Eviana Putri Hidayanti, Baiq Rauhil Mutmainah Mutmainah Sabirin Matsjeh Syarifah Asyura Yuli Kusuma Dewi