SINTESIS DAN IDENTIFIKASI STRUKTUR SENYAWA 3-(3,5-DINITROBENZOIL)-1-FENILTIOUREA SEBAGAI KANDIDAT ANTIKANKER

Susanti Susanti (Universitas Perjuangan Tasikmalaya)
Ruswanto Ruswanto (STIKes Bakti Tunas Husada)
Muharam Priatna (STIKes Bakti Tunas Husada Tasikmalaya)

Pharmacoscript
Vol. 1 No. 2 (2018): Pharmacoscript

Thiourea derivatives are known to be potential anticancer agents. 3-(3,5-dinitrobenzoyl)-1-phenylthiourea as a thiourea derivatives has been synthesized through acylation between 3,5-dinitrobenzoyl chloride and 1-phenylthiourea in tetrahydrofuran with triethylamine ascatalyst through reflux process with stirring for 6 hours. The percentage of yield was13,86%. The purity of the product was shown by the single spot on the TLC and narrowrange of melting point. The structure identification results with UV spectrophotometry, IRspectroscopy and 1HNMR spectroscopy showed that the structure of the product wasappropriate to the prediction.