Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
Vol 1, No 2 (2014): Wisuda Oktober 2014

SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI DARI SENYAWA 1-FENIL-3-(1-NAFTIL)-5-(2-KLOROFENIL)-2-PIRAZOLIN

Dahliarti ' (Unknown)
Hilwan Yuda Teruna (Unknown)
Jasril ' (Unknown)



Article Info

Publish Date
08 Sep 2014

Abstract

Pyrazoline is a bioactive compound but it is rare in nature. Pyrazoline has bioactivitieswhich are anti-inflammantory, antimicrobial, antibacterial, antidiabetic and antipyreticactivity. In this study this compound has been synthesized by reacting phenylhydrazinewith (E)-3-(2-chlorophenyl)-1-(naphtalen-1-yl)prop-2-en-1-one chalcone and thencatalyzed by acetic acid using microwave irradiation method. The yield of 1-phenyl-3-(1-naphtyl)-5-(2-chlorophenyl)-2-pyrazoline compound was 76,23%. This pyrazolinewas characterized using UV-Vis, IR, 1 H-NMR and 13 C-NMR spectrometer. Bioactivitytest showed that the pyrazoline compound does not have antibacterial activity againtGram-positive and Gram-negative bacteria.

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