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Jasril '
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SINTESIS DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA ANALOG PIRAZOLIN TURUNAN 3’BROMOKALKON INTI NAFTALEN Sriatun Sadiah; Yuharmen '; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Analog compound  of  3'bromochalcone  pyrazoline  derivative  5-  (3-bromofenil)  -3-(naphthalene-2-yl)  -1-fenill-4.5-dihydro-1H pirazol (PP2) was  synthesized through nucleophilic addition reactions using glacial acetic acid catalyst under microwave radiation. PP2  compound  was obtained as yellow crystal  with yield  of  77.73%.  The purity of pyrazoline analog coumpound has been tested using TLC  observation, determination of melting point,  HPLC  analysis  and characterized by UV spectroscopy, IR spectroscopy, Mass spectroscopy and NMR spectroscopy. Antibacterial test conducted by the agar diffusion method with concentration of 10 μg/disk dan 30 μg/disk against Gram-positive bacteria, B. subtilis and S. aureus, and Gram-negative bacteria, E. coli and S. typhi. PP2  compound  showed that there was a low antibacterial activity. However, the inhibition of PP2 against Gram-positive bacteria is greater than  that of Gram-negative bacteria.
SINTESIS KALKON TURUNAN PIRIDIN DARI ASETILTIOPEN DAN PIRIDINKARBALDEHID SERTA UJI ANTIOKSIDAN MENGGUNAKAN METODE DPPH Indah Fitria Ningsih; Nur Balatif; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

The compounds of condensation reaction have been synthesized using microwave irradiation with a base catalyst and their antioxidant activity were evaluated. One of the result of synthesized compounds was (4-hydroxy-2,6-di(pyridin-3-yl)-4-(thiophen-2-yl) cyclohexane-1,3-diyl) bis (thiophen-2-ylmethanone) (IF). The structure of the synthesizedproduct has been elucidated using IR, 1H-NMR, 13 1 C-NMR, mass-spectroscopic data and elemental analysis. The final product was screened for its antioxidant activity. The compound exhibited low DPPH (2,2’-diphenyl-1-picrylhydrazyl) scavenging activity which gave IC50 value > 500 ppm.
SINTESIS 3-(4-BROMOFENIL)-1-(NAFTALEN-1-IL)PROP-2-EN-1-ON DARI 1-ASETILNAFTALEN DENGAN 4-BROMOBENZALDEHID R. I. P. Sari; Yuharmen '; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcone of 3-(4-Bromo-phenyl)-1-naphthalen-1-yl-propenone was synthesizedby the stirring method in Claisen-Schmidt Condensation with NaOH as the catalyst. Thestructure of the compound was confirmed by 1 H-NMR, 13 C-NMR, IR, MS, and UVspectroscopy method. The compound produced was in 81.9% yields. Datacharacterization showed that the compound obtained was the targetted compound.
SINTESIS ANALOG 4-BROMO PIRAZOLIN DARI KALKON INTI NAFTALEN DENGAN KATALIS ASAM DAN UJI AKTIVITAS NYA SEBAGAI ANTIBAKTERI Desy Hariyanti; Hilwan Yuda Teruna; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Pyrazolines have been reported to possess  various  biological activities such as antimicrobial,  antidepressant,  antidiabetic,  anti-inflammatory,  antipyretic,  anticancer, and  anticonvulsant  activity. In this research, a halogenated pirazoline 5-(4-bromophenyl)-3-(naphthalene-1-yl)-4,5-dihydro-1H-pyrazole was synthesized  by cyclization  reaction between chalchone with hydrazine  hydrate  using acetate acid as catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by  UV,  IR, 1H-NMR, and 13C-NMR spectroscopy. The antibacterial activity of pyrazolines was determined using the agar diffusion method  against  Gram-negative bacteria:  Escherichia  coli  and  Salmonella  typhi  and  Gram-positive bacteria: Bacillus  subtilis  and  Staphylococcus  aureus. This compound  showed  inhibitory  activity against those four bacteria. Test results of antibacterial activity indicated that pyrazoline analogues were potential as antibiotics.
SINTESIS PIRAZOLIN DARI KALKON 3-KLORO INTI NAFTALEN DAN UJI AKTIVITASNYA SEBAGAI ANTIBAKTERI Ary Puspita; Hilwan Yuda Teruna; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Pyrazolines have been reported to possess many of interesting biological activities such as antimicrobial,  antidepressant,  antitumor, antioxidant, antiinflammatory, anticancer and  anticonvulsant  activity .  In this research, a  compound  of 1-phenyl-3-(2-naphthyl)-5-(3-chlorophenyl)-2-pyrazoline  was synthesized by cyclization of  (E)-3-(3-chlorophenyl)-1-naphthalene-2-yl-prop-2-en-1-on and phenylhydrazine  using glacial acetic acid  as  a  catalyst under  microwave  irradiation. The compound showed a good yield and  it  was characterized by UV, IR, 1 H-NMR  and 13 C-NMR  spectroscopy. The antibacterial activity of this compound was determined using agar diffusion method against Gram positive bacteria  (Bacillus subtilis  and  Staphylococcus aureus) and Gram negative bacteria  (Escherichia coli  and  Salmonella typhi). The compound showed very poor activity against Salmonella typhi.
ISOLASI METABOLIT SEKUNDER DAN UJI TOKSISITAS EKSTRAK METANOL DAGING BUAH TANAMAN Cerbera odollam Gaertn. (APOCYNACEAE) Nelma Yeni; Hilwan Yuda Teruna; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Cerbera odollam  Gaertn is a plant  found  in Indonesia which is used as traditional medicine. Isolation and toxicity assay on fruit flesh of this plant has  been  done. The methanol macerating method was applied to isolate the secondary metabolites from  part of this plant. The separation was carried out by vacuum liquid chromatography (VLC), gel chromatography and KLT preparative. Characterization of the fractions  was established using UV-Vis and FTIR spectroscopy. Toxicity assay was conducted by Brine Shrimp Lethality Test  (BSLT) method. The LC50  of  7th to 11th fractions of the methanol extract  were 107,86 ; 5,19; 136,42 ; 41,33 and 720,60 ppm, respectively. The 5th and 6th fractions were not toxic, the 11th fraction was toxic whereas other fractions were very toxic and potential to be used as an anticancer.
SINTESIS (E)-3-(3-BROMOFENIL)-1-(NAFTALEN-2-IL)PROP-2-EN-2-ON DARI 2-ASETILNAFTALEN DAN 3-BROMOBENZALDEHID I. Muttakin; N. Balatif; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Chalcone of (E)-3-(3-bromophenil)-1-(naphtalen-2-yl)prop-2-en-2-one has beensynthesized from 2- acethylnapthalene and 3- bromobenzaldehyd by aldol condensationusing the stirring method with base catalyst (NaOH). The yield obtained for thiscompound was 61.21 %. The purity of product has been evaluated using TLC, meltingpoint test, and HPLC analysis. The structure of the synthesized compound wasconfirmed by UV UV, FTIR, NMR, and MS analysis. Data characterization showed thatthe compound obtained was the targeted compound.
ISOLASI DAN UJI TOKSISITAS METABOLIT SEKUNDER EKSTRAK n-HEKSANA KULIT BATANG TUMBUHAN Polyalthia pulchra var. angustifolia King (ANNONACEAE) Yuhendri '; Jasril '; Yuharmen '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 1 (2014): Wisuda Februari 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

The secondary metabolites of the stem bark of Polyalthia pulchra were isolated andthan their toxicity activity assayed using Brine Shrimp Lethality Test (BSLT) method.The sample was extracted by maceration method using n-hexane solvent. Structures ofthe isolated compounds were conducted using Gas Chromatography and MassSpectrometry (GC-MS). The dried sample produced 3.21 g n-hexane extract (0.25%)and 0.032 g 2 nd fraction of n-hexane (FH2) (0.0025%). The toxicity assay showed thatn-hexane extract and FH2 fraction was toxic with LC 50 5.9 and 7.1 ppm. From theresults of GC–MS analysis, it is shown that FH2 fraction contains campesterol,stigmasterol, and γ-sitosterol compounds with retention times 75.605, 76.568 and,78.172 minutes, respectively.
ISOLASI METABOLIT SEKUNDER DAN UJI TOKSISITAS EKSTRAK METANOL KULIT BATANG TANAMAN Cerbera odollam Gaertn. (APOCYNACEAE) Wina Noviana Widaningsih; Hilwan Yuda Teruna; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Cerbera odollam  Gaertn. was used in traditional medicine as a laxative and antipyretic treatment of dysuria. This Apocynaceae family member contains terpenoid, steroid,   and several other chemical constituents, including iridoid that allegedly have cytotoxic activity. The  n-hexane and methanol macerating method was applied to isolate the secondary  metabolites  from the stem bark of this plant. The separation was carried out by vacuum liquid chromatography (VLC) and gel chromatography respectively. Characterization of the fractions was established using UV-Vis, FTIR, NMR,  and HR-MS spectroscopy which  produced a colored orange needless  cerbinal compound with melting point 188-189 0C. Toxicity assay was conducted by Brine Shrimp Lethality Test  (BSLT) method. The LC50 of 2nd, 3rd, 4th, 8th, 10  th, and  11th fractions of  each methanol extract  were  151.2; 56.96; 30.95; 3.37; 63.02 and 101.03 ppm, respectively. The 5th, 6th, and 9th fractions were not toxic  whereas other fractions were toxic and potential to be used as an anticancer.
SINTESIS KALKON PIRIDIN DAN TURUNANNYA DARI ASETILPIRIDIN DAN INDOL-3-KARBALDEHID SERTA UJI AKTIVITASNYA SEBAGAI ANTIOKSIDAN Juwita Oktavani; Hilwan Yuda Teruna; Jasril '
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

In this research, chalcones  of  acetylpyridine  derivatives  were synthesized  using stirrer method  with  a  base catalyst  (NaOH)  at room temperature. The compound  produced from the  synthesis  was  (E)-3-(1H-indole-3-yl)-1-(pyridine-3-yl)prop-2-en-1-one  (1).  The synthesized compound was  characterized using UV,  IR, NMR and Mass  Spectroscopy.  Its antioxidant activity was tested using DPPH method which  compound  (1)  showed mild antioxidant activity proved by IC 50 > 250 µg/mL.
Co-Authors Ary Puspita Dahliarti ' Desy Hariyanti Hilwan Yuda Teruna I. Muttakin Indah Fitria Ningsih Juwita Oktavani N. Balatif Nelma Yeni Nur Balatif R. I. P. Sari Sriatun Sadiah Wina Noviana Widaningsih Yuharmen ' Yuhendri '