Flavanones have been reported to possess many of interesting biological activities such as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and anti-HIV. In this research, a halogenated flavanone 2-(3 -bromophenyl)chroman-4-one was synthesized by cyclization of (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-propen-1-one using sodium acetate as catalyst under microwave irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1 H-NMR spectroscopy. The toxicity activity of this compound was determined using Brine Shrimp Lethality Test (BSLT) method against larvae Artemia salina Leach and showed a good activity with LC50 = 0,457 µg/mL. The result indicated that this compound was potential as anticancer.
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