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Ibnu Rush
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Mathematics

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SINTESIS DAN UJI TOKSISITAS ANALOG FLAVANON TERSUBSTITUSI HALOGEN Rush, Ibnu; Teruna, Hilwan Yuda; Zamri, Adel
Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam Vol 1, No 2 (2014): Wisuda Oktober 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam

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Abstract

Flavanones have been reported to possess many of interesting biological  activities  such as antimicrobe, antitumor, antioxidance, antiinflammatory, antimalaria, anticancer, and anti-HIV. In this research, a  halogenated flavanone 2-(3 -bromophenyl)chroman-4-one was synthesized by cyclization of  (E)-3-(3-bromophenyl)-1-(2-hydroxyphenyl)-2-propen-1-one  using  sodium  acetate as catalyst  under microwave  irradiation. The compound showed a good yield, and then was characterized by UV, IR and 1 H-NMR spectroscopy. The toxicity activity of this  compound was determined using Brine Shrimp Lethality Test (BSLT) method against larvae Artemia salina  Leach and showed a good activity with LC50  = 0,457 µg/mL. The result indicated that this compound  was potential  as anticancer.
Co-Authors Adel Zamri Hilwan Yuda Teruna