SINTESIS KALKON PIRIDIN DAN TURUNANNYA DARI ASETILPIRIDIN DAN INDOL-3-KARBALDEHID SERTA UJI AKTIVITASNYA SEBAGAI ANTIOKSIDAN

Juwita Oktavani
Hilwan Yuda Teruna
Jasril '

Jurnal Online Mahasiswa (JOM) Bidang Matematika dan Ilmu Pengetahuan Alam
Vol 1, No 2 (2014): Wisuda Oktober 2014

In this research, chalcones  of  acetylpyridine  derivatives  were synthesized  using stirrer method  with  a  base catalyst  (NaOH)  at room temperature. The compound  produced from the  synthesis  was  (E)-3-(1H-indole-3-yl)-1-(pyridine-3-yl)prop-2-en-1-one  (1).  The synthesized compound was  characterized using UV,  IR, NMR and Mass  Spectroscopy.  Its antioxidant activity was tested using DPPH method which  compound  (1)  showed mild antioxidant activity proved by IC 50 > 250 µg/mL.