This study was designed to evaluate the histopathogical effects of arsenic trioxide (ATO) on the some organsof rats , for this reason group of rats (15) were I/P inoculated with 1.5 mg /Kg .B.wt . daily for 30 days othergroup( 15 rat) treated with 100 mg/kg.B.wt of alphalipoic acid and ATO ( 1.5 mg/ kg.B.wt) for 30 .Theresults was revealed that the extensive pathological lesions in the liver , kidney , spleen and testes in all ratsexposed to arscenci trioxide due to the pathotoxic effect of ATO and decreased lesions were in the grouptreated with the alpha lipoic acid .100 mg / kg .B.wt) for 30 days as ameliorative or protective effect againstpathotoxicity of ATO .
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