Isoniazid Mono Resistance: Changing Trends in Drug Resistant Pulmonary Tuberculosis. – A Case Series of 3 Patients

Arti D. Shah1 , Anchal Jain2 , Apoorva3 , Kusum V. Shah4 , Yash Rana5 , Saket kumar6

Indian Journal of Forensic Medicine & Toxicology
Vol. 15 No. 1 (2021): Indian Journal of Forensic Medicine & Toxicology

Drug resistant tuberculosis is a major public health concern in many countries including India, Isoniazidresistance (INH) accounts for 7.2 % of new cases globally.1In our case series 3 patients had INH monoresistance out of which 2 patients had no previous history anti tuberculosis therapy (ATT). All 3 patientsreceived 6 months of standard regimen under National Tuberculosis Elimination Programme (NTEP).All patients showed clinical improvement. INH mono resistance diagnosis is often delayed due to lack ofinfrastructure of 1st line probe assay (LPA) at various centres. INH mono resistance if diagnosed early canalso help in prevention of Multi drug resistant tuberculosis (MDR TB)