Oral Administration of The Hypercholesterol Rat Feed Formula to Making The Animal Dyslipidemia Model on Sprague Dawley Rats

Fatchiyah Fatchiyah (1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Indonesia 2) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia)
Eko Suyanto (1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Indonesia 2) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia)
Rista Nikmatu Rohmah (1) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia 2) Institute Biosains, Universitas Brawijaya, Malang)
Lidwina Faraline Triprisila
Hazna Noor Meidinna (1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Indonesia 2) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia)
Dewi Ratih Tirto Sari (1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Indonesia 2) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia)
Iva Himmatul Aliyah (1) Departemen Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Brawijaya, Indonesia 2) Research Center of Smart Molecule of Natural Genetics Resources (SMONAGENES), Universitas Brawijaya, Indonesia)

Biotropika
Vol 9, No 2 (2021)

The aim of this study was to make animal dyslipidemia models in Sprague Dawley strains induced by a high fat goat diet formula as hypercholesterol feed for two months. The experimental animal used in this study was 30 male rats (Rattus norvegicus strain Sprague Dawley) with an age of 2-3 months with an average body weight of 150g. Animal models are divided into two groups consisting of a control group without additional diet and dyslipidemia group given food consumption goat hypercholesterolemia with high-fat diet formula orally every day for two months. Physiological characteristics of dyslipidemia SD rats had higher body weight, increased food consumption and fecal weight, and decreased water intake and urine volume than the control group. Total cholesterol, triglyceride, and LDL-cholesterol levels increased, while HDL-cholesterol levels did not change in the dyslipidemia rats group compared to the control group. The conclusion of this study indicated that the hypercholesterol diet formula with a high composition of goat fat was successfully induced the SD rats to become dyslipidemia model rat with specific hypercholerol characteristics.