Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac

Gabena Indrayani Dalimunthe (Department of Pharmacy, Universitas Muslim Nusantara Al Washiyah, Jalan Guru II Medan, Sumatra Utara, Indonesia.)
Ricky Andi Syahputra (Department of Chemistry, Universitas Negeri Medan, Sumatra Utara, Indonesia)

Journal Syifa Sciences and Clinical Research (JSSCR)
Vol 3, No 2 (2021): Volume 3 Edisi 2 2021

Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.