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All Journal Jurnal Biologi Tropis Window of Health : Jurnal Kesehatan Journal Syifa Sciences and Clinical Research (JSSCR) AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Dunia Farmasi Jurnal Ilmiah Manusia dan Kesehatan PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) Indonesian Journal of Chemical Science and Technology Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma Indonesian Journal of Pharmaceutical Education JUKESHUM: Jurnal Pengabdian Masyarakat FORTE JOURNAL Jurnal Farmanesia Journal of Health and Medical Science International Journal of Health and Pharmaceutical (IJHP) Student Scientific Creativity Journal Cross-border Jurnal Pengabdian West Science FARMASAINKES Nusantara Scientific Medical Research Journal Usada Nusantara: Jurnal Kesehatan Tradisional Jurnal Ilmu Kesehatan dan Gizi Journal of Pharmaceutical and Sciences. Scientica: Jurnal Ilmiah Sains dan Teknologi FASKES : Jurnal Farmasi, Kesehatan, dan Sains Medic Nutricia : Jurnal Ilmu Kesehatan Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Indonesian Journal of Science and Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan As-Salam: Journal Islamic Social Sciences And Humanities
Gabena Indrayani Dalimunthe
Program Studi Farmasi, Fakultas Farmasi, Universitas Muslim Nusantara Al-Washliyah, Medan, Indonesia
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Edge Activator: Effect of Concentration Variation of Tween 80 on Characteristics and Rate of Difusion transfersome sodium diclofenac Gabena Indrayani Dalimunthe; Ricky Andi Syahputra
Journal Syifa Sciences and Clinical Research Vol 3, No 2 (2021): Volume 3 Edisi 2 2021
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v3i2.11914

Abstract

Diclofenac sodium is a Transfersom is a transdermal delivery system consisting of phospholipids and edge activators. Transfersom increases the size of the stratum corneum lipid barrier pores, then enters the skin through the drive of the trans-barrier motion and squeezes itself to follow the lipid barrier pore size. The purpose of this study is to determine the effect of the tween-80 concentration as an edge activator on the characteristics and diffusion rate of diclofenac sodium transfersom. Transferom preparation used the vortex-sonication method which was made in five formulae with variations in the concentration ratio of phosphatidylcholine and tween-80 (95:05, 90:10, 85:15, 80:20, and 75:25). The results show that all five formulae have different morphological forms. The results of statistical tests using One-Way ANOVA finds a significant effect (p-value) of the edge activator concentration on the diffusion rate of diclofenac sodium transfersom.
NARKOBA, BAHAYA DAN CARA MENGANTISIPASINYA Ahmad Darwis; Gabena Indrayani Dalimunthe; Sulaiman Riadi
AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Vol. 1 No. 1 (2017): Amaliah: Jurnal Pengabdian Kepada Masyarakat
Publisher : LP2M UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v1i1.14

Abstract

Penyalahgunaan narkoba di kalangan pemuda dan remaja tidak dapat dipungkiri ternyata masih banyak yang mengkonsumsinya di lingkungan sekitar kita. Dampaknya bagi kesehatan dan masa depan tidaklah sedikit. Bahaya narkoba bagi pecandu dan kalangan muda, para pelajar sangat banyak dan jika tidak segera dihentikan kebiasaan mengkonsumsi narkoba maka hal ini akan memperburuk derajat kesehatan penggunanya itu sendiri secara pelan pelan tapi pasti serta akan merusak masa depan kehidupan mereka.. Dalam kehidupan bermasyarakat para pemuda atau pelajar membutuhkan suasana lingkungan yang kondusif dan nyaman dari penyalahgunaan narkoba, oleh karena itu penanggulangan narkoba menjadi tanggung jawab bersama dimulai dari keluaraga, kemudian masyarakat dan pemerintah. Melalui kegiatan pengabdian ini diharapkan mampu memberikan pemahaman kepada masyarakat di kabupaten karo tentang bahaya yangdiderita akibat penyalahgunaan narkoba , jenis jenis dan macam-macam narkotika serta bagaimana cara menanggulanginya. Metode yangdigunakan dalam menanggulangi narkoba adalah memberikan presentasi pemahaman yang benar tentang narkoba serta adanya diskusi tanya jawab seputar jenis jenis narkoba, bahayanya dan langkah langkah yang efektif agar masyarakat di Kabupaten Karo dapat menanggulanginya terlebih dahulu harus dimulai dari pribadi masing-masing keluarga, kemudian masyarakat dan pemerintah.
PKM PENYULUHAN PENGGUNAAN ANTIBIOTIK KEPADA MASYARAKAT DESA TEMBUNG Minda Sari Lubis; Debi Meilani; Rafita Yuniarti; Gabena Indrayani Dalimunthe
AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Vol. 3 No. 1 (2019): Amaliah: Jurnal Pengabdian Kepada Masyarakat
Publisher : LP2M UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v3i1.246

Abstract

Antibiotik merupakan obat yang penting digunakan dalam pengobatan infeksi akibat bakteri. Tingginya penggunaan antibiotika yang tidak tepat pada masyarakat disebabkan kurangnya pengetahuan tentang antibiotika yang menyebabkan meningkatnya masalah resistensi antibiotika. Pengabdian masyarakat ini bertujuan untuk melihat bagaimana tingkat pengetahuan masyarakat di Desa Tembung tentang penggunaan antibiotika. Pengabdian masyarakat ini merupakan Pengabdian masyarakat deskripsi, dengan metode pendekatan crosssectional, menggunakan instrumen berupa kuesioner. Total 30 responden dalam Pengabdian masyarakat ini adalah penduduk Lingkungan III, Kelurahan Tembung, Kecamatan Medan Tembung, Kota Medan. Hasil yang diperoleh dari pengabdian ini adalah peningkatan pengetahuan masyarakat di Desa Tembung entang penggunaan antibiotik yang tepat. Adapun Kesimpulan kegiatan ini adalah edukasi dan Penyuluhan dapat meningkatkan pengetahuan masyarakat tentang penggunaan antibiotika.
Formulasi Sediaan Gummy Candies Sari Brokoli (Brassica Oleracea L.) Dengan Variasi Sukrosa Sebagai Pemanis Niza Fonna, Gabena Indrayani Dalimunthe
Journal of Health and Medical Science Volume 1 Nomor 2 April 2022
Publisher : Journal of Health and Medical Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.828 KB)

Abstract

Broccoli belongs to the cabbage family and includes vegetables that are not resistant to hot air. Broccoli is efficacious to accelerate the healing of the disease and prevent and inhibit the development of cancer cells in the body, especially hormone-related cancers, such as breast cancer in women, and prostate cancer that threatens men. Therefore, it is very potential to be developed and made in gummy candies preparations so that consumers can be consumed for all ages (especially children). The objective of the research was to find out broccoli essence can be formulated into gummy candies with variations of sucrose as sweetener, test the quality of broccoli candies gummy candies preparations resulting from various physical tests and the results of the favorite level of gummy candies from broccoli essence with variations in sucrose levels as sweetener. In this research used formula 1 with the amount of sucrose levels 115 mg, formula 2 with the amount of sucrose levels 230 mg, formula 3 with the amount of sucrose content 345 mg, formula 4 with the amount of sucrose content 460 mg and formula 5 with the amount of sucrose levels 575 mg. Based on the results of the research, broccoli essence could be formulated into gummy candies preparations with sucrose variations, had an attractive shape and color with a distinctive odor, as well as a chewy texture and has a pH of 5 that was suitable for gummy candies, the results of the favorite level test showed formula 5 was the preferred one with a variation in sucrose levels of 575 mg. Variations in sucrose levels had an effect on the level of liking.
Formulasi Sediaan Gummy Candies Sari Sawi Pakcoy (Brassica Rapa L) Dengan Variasi Sukrosa Sebagai Pemanis Liza Zulaini, Gabena Indrayani Dalimunthe
Journal of Health and Medical Science Volume 1 Nomor 2 April 2022
Publisher : Journal of Health and Medical Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (198.807 KB)

Abstract

Pakcoy (Brassica rapa L.) is a type of green vegetable that is still a group with mustard. Pakcoy is a vegetable of immigrants from abroad. This vegetable is popular especially among people of Chinese descent. Sawi pakcoy contains vitamin A and vitamin C. The use of sawi pakcoy as a nutraceutical product is still relatively rare. The objective of this research was to find out that sawi pakcoy juice (Brassica rapa L.) can be made into preparations nutraceutical gummy candies and can find out which formula respondents prefer the most and the results of the best physical evaluation in gummy candies preparations. Samples of sawi pakcoy were formulated into gummy candies preparations with variations in sucrose concentrations of 115 mg, 230 mg, 345 mg, 460 mg, and 575 mg. All preparations were tested by organoleptic testing, weight uniformity, pH test, stability and hedonics by respondents of color, taste, aroma/smell, shape, and texture, then the results were compared to requirements in the literature. The results of the evaluation of gummy candies preparations state that gummy candies preparations meet physical quality. From the data it could be concluded that the preparation of gummy candies from sawi pakcoy’s essence showed the most preferred test results of gummy candies preparations, namely formula 5 with sucrose levels of 575 mg. The coefficient value of variation for the weight uniformity test was best compared to other formulas was formula 5 which was 575 mg. The pH value for the entire formula was 5. From stability tests it was known that the most stable formula was formula 5 which was stored at room temperature (25 °C).
Antipyretic Activity Test of Combination of Peperomia pellucida Extract and Andrographis paniculata in Mice (Mus musculus) Khairil Pahmi; Muhammad Ricky Ramadhian; Gabena Indrayani Dalimunthe
Indonesian Journal of Pharmaceutical Education Vol 2, No 3 (2022): September-Desember 2022
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v2i3.15654

Abstract

Pepper elder (Peperomia pellucida) and green chiretta (Andrographis paniculata) are plants that have been used empirically to reduce fever. Fever is a symptom of a disease characterized by a significant increase in body temperature. This study aimed to determine the antipyretic effect of the combination of pepper elder herbal extract (P. pellucida) and green chiretta herbal extract (A. paniculata) (80:20) in the male house mice (Mus musculus). Extraction was conducted through maceration using ethyl acetate solvent. The total of 25 male mice were divided into 5 groups, namely a negative control group (Na-CMC 1%), a positive control group (paracetamol), and a treatment group induced by a combination of pepper elder herbal extracts and green chiretta herbal extract at the dose of (80 + 20), (40 +10), and (20 + 5) mg/kg BW. DPT vaccine 0.2 ml was used intramuscularly as a fever inducer. The observation was carried out at 30, 60, 90, and 120 minutes after treatment. The data obtained were analyzed using one-way ANOVA followed by the LSD test to determine the differences between groups. The results showed that variations in the dose of the combination of pepper elder and green chiretta herbal extracts had an antipyretic effect where the most effective dose was (80 + 20) mg/kg BW due to its stable temperature reduction power and effectiveness that are equivalent to paracetamol. The combination of suruhan herb extract (P. pellucida) and sambiloto herb (A. paniculata) has potential as an antipyretic
Caffeine Levels from Various Types of Coffee Drink Packaging Circulated in the Medan City Market Were Examined Using a UV Spectrophotometry Method Gabena Indrayani Dalimunthe; Adli Nuzula Rahmah; Zulmai Rani; Yayuk Putri Rahayu
Indonesian Journal of Chemical Science and Technology (IJCST) Vol 5, No 2 (2022): JULI 2022
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/ijcst.v5i2.37465

Abstract

Coffee drinks are drinks that come from the processing and extraction of coffee beans. One of which is caffeine. Coffee contains approximately 24 of the most important substances. The purpose of this study was to determine the level of caffeine in coffee drinks from various types of packaging. The research stages include sample collection and preparation; identification of caffeine content; and examination of caffeine levels using UV spectrophotometry. The results showed that the three samples of coffee drinks sold at the minimarket in Jermal, Medan contained caffeine, and the levels of caffeine in coffee drinks were 26,352±0,292 mg/100mL (Sample A), 15,179±0,286 mg/100mL (Sample B), and 7,965±0,98 mg/100mL (Sample C). The caffeine content obtained meets the requirements of SNI, where the maximum amount of caffeine that can be consumed by the public in a day based on SNI is 50 mg–150 mg.
Aktivitas Antibakteri Ekstrak Etanol Lidah buaya (Aloe Vera L.) Terhadap bakteri Propionibacterium acnes Sry Lanna Zahara, Minda Sari Lubis, Gabena Indrayani Dalimunthe, Haris Munandar Nasution
Journal of Health and Medical Science Volume 1 Nomor 2 April 2022
Publisher : CV. Pusdikra Mitra Jaya

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Abstract

Tanaman Lidahibuaya (Aloeivera L.) di Indonesia telah lamaidibudidayakan olehimasyarakat sebagaiitanaman obat keluargaisekaligus tanamanihias karenaibentuknya yangiunik. Lidahibuaya diketahui mengandung antrakuinon, saponin dan tanin yang memiliki sifat antibakteri. Kulit luar dan tengahibanyak mengandungiantrakuinon yangimemiliki efek antibakteri, sedangkanikulitidalam mengandung saponin yang juga memiliki efek antibakteri. Penelitianiini bertujuan untukimengetahui bahwa ekstrakietanol lidahibuaya memiliki kemampuan menghambatidan membunuhibakteri Propionibacteriumiacnes. dibuat secara maserasi dengan etanol 96%, kemudian dilakukan skrining fitokimia terhadap ekstrak. Ekstrakietanol lidah buayao(Aloe veraiL.) dibuat dalamilarutan uji konsentrasi yangiberbeda yaitu 3,125%,i6,25%,i12,5% dan 50%.iKontrol positifiyang digunakaniadalah tetrasiklin danikontrol negatifnyaiadalah DMSO.Hasil penelitian menunjukkanibahwa ekstrakietanol lidahibuaya mengandung flavonoid,osaponin, tanin, steroid/triterpenoididan antrakuinon. Konsentrasi hambat minimum (KHM)pditentukanidengan mengamati kekeruhanisecaraiin vitro danikonsentrasiibunuhiminimum (KBM) ditentukan dengan menghitung keberadaan koloni Propionibacterium acnes dalam cawan Petri. Berdasarkanipenelitian yang dilakukanidapat disimpulkanibahwa ekstrakietanol lidahibuaya mampu menghambatipertumbuhan Propionibacterium acnes pada konsentrasi 12,5% sebagai hambat minimum dan pada konsentrasi 25% sebagai bunuh minimum
Uji Aktivitas Analgesik Ekstrak Daun Timun Tikus (Coccinia Grandis (L). Voight) Terhadap Mencit Jantan (Mus Musculus) Rani Afriani, D. Elysa Putri Mambang, Gabena Indrayani Dalimunthe, Haris Munandar Nasution
Journal of Health and Medical Science Volume 1 Nomor 2 April 2022
Publisher : CV. Pusdikra Mitra Jaya

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Abstract

Analgesik merupakan zat yang meredakan atau menghilangkan rasa sakit tanpa kehilangan kesadaran. Tidak semua tanaman aman dikonsumsi, namun obat tradisional biasanya mempunyai efek samping lebih sedikit dibanding obat sintetik. Daun timun tikus mengandung flavonoid yang bekerja sebagai analgetik, dimana akan menghambat kerja enzim siklooksigenase sehingga akan mengurangi rasa nyeri. Tujuan penelitian ini adalah untuk mengetahui kandungan metabolit sekunder, aktivitas analgesik, dan membandingkan aktivitas analgesik ekstrak daun timun tikus (Coccinia grandis (L). Voight) dengan kontrol positif metampiron 1%. Ekstrak daun timun tikus (Coccinia grandis (L). Voight) dibuat secara maserasi dengan etanol 96%, kemudian dilakukan skrining fitokimia terhadap serbuk dan ekstrak. Uji aktivitas analgesik menggunakan mencit jantan yang diinduksikan asam asetat, selanjutnya diberi perlakuan ekstrak daun timun tikus dosis 200mg/kgBB, 300mg/kgBB, dan 400mg/kgBB, kontrol negatif CMC 0,5%, dan metampiron 1% sebagai kontrol positif yang dilihat jumlah geliat tiap 5 menit selama 1 jam. Kemudian dihitung persentase daya analgesik dan persentase efektivitas analgesik. Hasil penelitian menunjukkan bahwa daun timun tikus (Coccinia grandis (L). Voight) mengandung alkaloid, flavonoid, saponin, tanin, dan steroid. Ekstrak daun timun tikus (Coccinia grandis (L). Voight) memiliki aktivitas analgesik, dan ekstrak daun timun tikus (Coccinia grandis (L). Voight) dosis 400mg/kgBB paling mendekati aktivitas analgesiknya dengan kontrol positif metampiron 1%.
Uji Sitotoksisitas Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Dengan Metode Brine Shrimp Lethality Test (BSLT) Raihan, Gabena Indrayani Dalimunthe
Journal of Health and Medical Science Volume 1 Nomor 3 Juli 2022
Publisher : CV. Pusdikra Mitra Jaya

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Abstract

Bunga Telang bukan hanya sekedar tanaman hias tapi banyak di manfaatkan sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui golongan senyawa metabolit sekunder yang terkandung dalam ekstrak etanol bunga telang dan daya sitotoksisitas ekstrak etanol bunga telang dengan melihat nilai LC50 yang diujikan dengan menggunakan metode Brine Shrimp Lethality Test (BSLT). Penelitian ini meliputi skrining fitokimia ekstrak bunga telang dengan metode Brine Shrimp Lethality Test (BSLT) untuk melihat jumlah kematian larva Artemia salina leach (LC50). Hasil pengujian skrining fitokimia menunjukkan bahwa bunga telang positif mengandung flavonoid, alkaloid, saponin, tanin, steroid. Hasil dari karakterisasi serbuk simplisia bunga telang diperoleh kadar air 6,66%, kadar sari larut dalam air 47,7%, kadar sari larut dalam etanol 38%, kadar abu total 6,03%, dan kadar abu tidak larut asam 0,60%. Hasil uji sitotoksisitas dengan analisis probit menunjukkan nilai LC50 yaitu 264,7890 µg/mL sehingga dapat disimpulkan bahwa ekstrak etanol bunga telang bersifat toksik dan berpotensi sebagai antikanker.
Co-Authors Adani, Bazlina Adela Octi Dwiyani Adli Nuzula Rahmah Agustina, Meri Ahmad darwis Alma Dhita Shafira Andi Syahputra, Ricky Anny Sartika Daulay Anugrah, Bayu Arianti, Sellin Arina Ashar, Diya Asparyzha, Rhyzha Aulia Fitri, Aulia Aulia, Meisyah Bambang Hermanto Basaniah Basaniah Chairina Milda Chandra, Putra Cindy Marlina Tambunan Claudy Friesta Melanie Cut Erika Maulydya D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Debi Meilani Dena, Mutia Dewa, Fasca Dikki Miswanda Dina Sri Novita Dina Veranika Dinda Sari Utami Dison Silalahi, Alistraja Emmy Wiriandini Fadhilah M, Ihsan Fadillah, Nike Fathur Rahman Febiyani, Rica Fithri Pulungan, Ainil Fitri Febriani Fitri, Raissa Ginting, Ovalina Sylvia Br. Girsang, Raflika Azwanda Gita Dwi Puspa Fadillah Hamda, Haikal Handayani, Riska Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Humairah, Dwina Angelina Husna, Miftahul husna, nadiatul Ilmi Widya Sari Isnaria, Vita Jurida, Wike Juwita, Sukma Karlina Butar Butar Kartika, Dinda Dwi Khairil Pahmi Khairunnisa , Ardina Kiki Rawitri Latifah Sahara Pulungan Lestari, Amanda Putri Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisa Amalia Lubis, Aisyah Putri Lubis Lubis, Minda Sari M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Mambang, Elysa Putri Mauliza, Syarifah Misna Rosalinda Hutabarat Muhammad Amin Nasution Muhammad Ricky Ramadhian Muhammad Tegar Tri Rizky Mutiara Rahmah Nasri Nasri, Nasri Nasution, M. Pandapotan Nasution, Nur Sahadah Nasution, Shamila Sufi Aulia Nasution, Vevi Sarah Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Niswa, Khairun Novita Sari, Helsa Nur Asia, Nur Nur, Hijrotun Nuraisyah Nurfadilla, Kiki Nurliansyah, Nurliansyah Nurmala, Dewi Nurul Haliza Lubis Nurul Hidayah Nurul Salsa Abya Ritonga Olita, Apen Peri , Peri Peri, Peri Puteri, Cut Intan Annisa Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rahma Dona, Rahma Rahma Maulidia Fitri Rahmi , Ulfa Rambe, Robiatun Rambe, Sitiapsah Rangkuti, Cindy Rahayu Rawitri, Kiki Riani, Nur Aslin Ricky Andi Syahputra Ridwan Taher Lubis Ridwanto Ridwanto Rima Marwarni Rina Azhari Risnayanti Ritonga, Oktavia Riza Syafira Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga sahrianti, Hikmah Samosir, Anzly Hasian Samran, Samran Saragih, Aqilah Mutmainnah Sari Lubis , Minda Sari Lubis, Winda Sari, Syilvi Rinda Sartika Daulay, Anny Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu Silvia Sinaga, Rosalinda Mahdalena Siregar, Hikmatussabaria Siti Anisa Siti Anisa Sitinjak, Iyustri Ririn Situmorang, Lusi Grasia Sri Mulia Ningsih Siregar Sri Wahyuni Sri Wahyuni Sulaiman Riadi Sulwiyatul K Sani Syahputri, Maulida Syarifah Aulia Tasya Ardana Ummu Safura Sirait Vera Estefania Kaban Wardah Tulail Nadila Widya Sari Winda Aulia Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Apriani Br.Lubis Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Anisa Zahira Ahmad, Madani Ziza Putri Aisyia Fauzi Zulmai Rani