Analisis Metabolit Sekunder dan Aktivitas Ekstrak Etanol Kulit Buah Salak (Salacca zalacca (Gaertn.) Voss) Terhadap Kadar Glukosa dan Ureum Kreatinin Tikus Putih Jantan (Rattus norvegicus): Analysis of Secondary Metabolites and Activity of Ethanol Extract of Snake Fruit Peel (Salacca zalacca (Gaertn.) Voss) on Glucose and Ureum Creatinine Levels of Male White Rats (Rattus norvegicus)

Tien Wahyu Handayani (Program Studi S1 Farmasi, STIFA Pelita Mas Palu)
Agustinus Widodo (Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako)
Risna Yanti (Program Studi S1 Farmasi, STIFA Pelita Mas Palu)
Erdy Prasetyo (Program Studi S1 Farmasi, STIFA Pelita Mas Palu)
Zulfaidah (Program Studi S1 Farmasi, STIFA Pelita Mas Palu)
Joni Tandi (Program Studi S1 Farmasi, STIFA Pelita Mas Palu)

KOVALEN: Jurnal Riset Kimia
Vol. 7 No. 3 (2021): Edisi Desember

The snake fruit peel (Salacca zalacca (Gaertn.) Voss) traditionally has several health benefits, one of which is to treat diabetes mellitus. This study aimed to determine the content of secondary metabolites in the ethanolic extract of snake fruit peel and its activity on glucose and urea creatinine levels in male white rats (Rattus norvegicus). Phytochemical screening of extracts was carried out qualitatively and quantitatively using UV-Vis Spectrophotometry. This study is a laboratory experimental study using 30 test animals divided into 6 treatment groups (normal control, negative control, positive control, 70 mg/kg BW, 140 mg/kg BW, and 280 mg/kg BW). The results showed that the ethanol extract of the bark of the salak fruit contained 7.61 %w/w alkaloids, flavonoids 0.041% w/w, tannins 1.18% w/w, and saponins 2% w/w. Ethanol extract of salak fruit peel dose of 140 mg/kg BW affected decreasing blood glucose and urea creatinine levels. The skin of the salak fruit has the potential to be further investigated as an antidiabetic.