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All Journal KOVALEN: Jurnal Riset Kimia
Erdy Prasetyo
Program Studi S1 Farmasi, STIFA Pelita Mas Palu
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Analisis Metabolit Sekunder dan Aktivitas Ekstrak Etanol Kulit Buah Salak (Salacca zalacca (Gaertn.) Voss) Terhadap Kadar Glukosa dan Ureum Kreatinin Tikus Putih Jantan (Rattus norvegicus): Analysis of Secondary Metabolites and Activity of Ethanol Extract of Snake Fruit Peel (Salacca zalacca (Gaertn.) Voss) on Glucose and Ureum Creatinine Levels of Male White Rats (Rattus norvegicus) Tien Wahyu Handayani; Agustinus Widodo; Risna Yanti; Erdy Prasetyo; Zulfaidah; Joni Tandi
KOVALEN: Jurnal Riset Kimia Vol. 7 No. 3 (2021): Edisi Desember
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2021.v7.i3.15567

Abstract

The snake fruit peel (Salacca zalacca (Gaertn.) Voss) traditionally has several health benefits, one of which is to treat diabetes mellitus. This study aimed to determine the content of secondary metabolites in the ethanolic extract of snake fruit peel and its activity on glucose and urea creatinine levels in male white rats (Rattus norvegicus). Phytochemical screening of extracts was carried out qualitatively and quantitatively using UV-Vis Spectrophotometry. This study is a laboratory experimental study using 30 test animals divided into 6 treatment groups (normal control, negative control, positive control, 70 mg/kg BW, 140 mg/kg BW, and 280 mg/kg BW). The results showed that the ethanol extract of the bark of the salak fruit contained 7.61 %w/w alkaloids, flavonoids 0.041% w/w, tannins 1.18% w/w, and saponins 2% w/w. Ethanol extract of salak fruit peel dose of 140 mg/kg BW affected decreasing blood glucose and urea creatinine levels. The skin of the salak fruit has the potential to be further investigated as an antidiabetic.
Co-Authors Agustinus Widodo Joni Tandi, Joni Risna Yanti Tien Wahyu Handayani Zulfaidah