In an effort to find new sources of medicinal plants as antimalarials based on ethnobotany knowledge from generation to generation. Therefore, tested the inhibition of heme polymerization from 70% ethanol extract of papaya leaves (Carica papaya) and Guava (Psidium guajava) leaves. The data obtained were calculated by IC50 using SPSS 22 obtained that 70% ethanol extract of Pepaya leaves (Carica papaya) and Jambu Biji leaves (Psidium guajava) had antimalarial activities of 7,914 and 8,794 mg/ml respectively and their had the potential to be developed in more research further as antimalarial.
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