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All Journal VALENSI Jurnal Kimia (Journal of Chemistry) Journal of Mathematical and Fundamental Sciences Journal of Islamic Pharmacy JOPS (Journal Of Pharmacy and Science) Jurnal Farmasi Higea Jurnal Ilmiah Pharmacy Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Makara Journal of Science Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Hadi Kuncoro
Faculty Of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Physics Public Health

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TOXICITY STUDY OF PARE LEAF EXTRACTS (MOMORDICA CHARANTIA) TO CULEX PIPIENS MOSQUITO LARVAE Annisa, Rahmi; Amir, Muhammad; Kuncoro, Hadi
Journal of Islamic Pharmacy Vol 2, No 2 (2017): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v2i2.4506

Abstract

This study aims to determine the yield, toxicity, and toxic concentration of crude extracts of ethanol, n-hexane fraction extract, ethyl acetate fraction extract and n-butanol fractions extract pare leaf (Momordica charantiaL.) larvae Culex pipiens. The method used to determine the toxicity of extract larvasida test larvae Culex pipiens to obtain the LC99 values obtained using the analysis of Reed and Muench. Extraction and fractionation processis known to yield a ethanol crude extract obtained 8.86%, n-hexane fraction extract of 1%, ethyl acetate fraction extract 1.80% and n-butanol fractions extract of 0.80% and the toxicity obtained test results that pare leaf (Momordica charantia L.) have the potential toxicity larvae larvae of Culex pipiens as indicated by the value by Lethality Concrentation 99 % (LC99) in the crude extract ethanol 7416.52  ppm, n-hexane fraction extract of 2564.48 ppm, ethyl acetate fraction extract 2702.09 ppm and n-butanol fractions extract of 2665.63 ppm. Keywords: Pare leaf (Momordica charantia L.), toxicity, larvae Culex pipiens
Stigmast-5(6)-en-3(6)-ol dari Herba Tumbuhan Krokot (Lygodium microphyllum) Hadi Kuncoro; Kindi Farabi; Euis Julaeha; Laode Rijai; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 1, No. 1, Mei 2015
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.678 KB) | DOI: 10.15408/jkv.v0i0.3152

Abstract

A steroid, stigma-5(6)-en-3β-ol or β-sitosterol (1) had been isolated from a n-hexane extract of the Krokot plant herb (Lygodium microphyllum). The chemical structure of 1 was identified on the basis of spectroscopic evidences and by comparison with those of spectra data previously reported. The investigation of steroid, stigma-5(6)-en-3β-ol was from L. microphyllum plant was reported inthis research for first time.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3152
Stigmast-5(6)-en-3(6)-ol dari Herba Tumbuhan Krokot (Lygodium microphyllum) Hadi Kuncoro; Kindi Farabi; Euis Julaeha; Laode Rijai; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 1, No. 1, Mei 2015
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.678 KB) | DOI: 10.15408/jkv.v0i0.3152

Abstract

A steroid, stigma-5(6)-en-3β-ol or β-sitosterol (1) had been isolated from a n-hexane extract of the Krokot plant herb (Lygodium microphyllum). The chemical structure of 1 was identified on the basis of spectroscopic evidences and by comparison with those of spectra data previously reported. The investigation of steroid, stigma-5(6)-en-3β-ol was from L. microphyllum plant was reported inthis research for first time.DOI :http://dx.doi.org/10.15408/jkv.v0i0.3152
FLAVONOLS FROM THE LEAVES Lygodium microphyllum (Lygodiaceae) Hadi Kuncoro; Kindi Farabi; Euis Julaeha; Laode Rijai; Yoshihito Shiono; Unang Supratman
Jurnal Kimia (Journal of Chemistry) Vol. 11. No. 1 Januari 2017
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.797 KB) | DOI: 10.24843/JCHEM.2017.v11.i01.p02

Abstract

Flavonol compounds, quercetin (1) and quercetin-3-O-?-D-glucopyranoside (2) have been isolated from the ethyl acetate extract of Lygodium microphyllum leaves. The chemical structures of flavonol compounds were identified based on spectroscopic data and by comparison of spectral data obtained previously. The discovery of flavonol compounds in Lygodium microphyllum was shown in this study for the first time.
Flavonoid Compounds from the Herb of Krokot (Lygodium microphyllum) and their antioxidant activity against DPPH Hadi Kuncoro; Kindi Farabi; Laode Rijai; Euis Julaeha; Unang Supratman; Yoshihito Shiono
Journal of Mathematical and Fundamental Sciences Vol. 50 No. 2 (2018)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2018.50.2.7

Abstract

Six flavonoid compounds, kaempferol (1), quercetin (2), acacetin (3), quercetin-3-O-β-D-glucopyranoside (4), kaempferol-3-O-β-D-glucopyranoside (5), and isorhamnetin-3-O-β-D-glucopyranoside (6), were isolated from the methanol extract of the Lygodium microphyllum herb. The chemical structures of compounds 1-6 were identified on the basis of spectroscopic evidence and comparison with previously reported spectral data. Compounds 1-6 were isolated for first time from this plant. Their antioxidant activity against DPPH (2,2-Diphenyl-1-picrylhydrazyl) was evaluated. Among the compounds, quercetin (2) showed high antioxidant activity with IC50 values of 6.94 ± 0.03 μg/mL.
AKTIVITAS ANTIMALARIA PENGHAMBATAN POLIMERISASI HEME EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava) DAN DAUN PEPAYA (Carica papaya) M. Arifuddin; Mahfuzun Bone; Rolan Rusli; Hadi Kuncoro; Islamuddin Ahmad; Laode Rijai
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 1 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (181.964 KB) | DOI: 10.36387/jiis.v4i1.246

Abstract

In an effort to find new sources of medicinal plants as antimalarials based on ethnobotany knowledge from generation to generation. Therefore, tested the inhibition of heme polymerization from 70% ethanol extract of papaya leaves (Carica papaya) and Guava (Psidium guajava) leaves. The data obtained were calculated by IC50 using SPSS 22 obtained that 70% ethanol extract of Pepaya leaves (Carica papaya) and Jambu Biji leaves (Psidium guajava) had antimalarial activities of 7,914 and 8,794 mg/ml respectively and their had the potential to be developed in more research further as antimalarial.
ISOLASI, KARAKTERISASI DAN AKTIFITAS RADIKAL BEBAS DPPH SENYAWA METABOLIT SEKUNDER DARI FRAKSI ETIL ASETAT DAUN KOKANG (Lepisanthes amoena (Hassk) Leenh.) Hadi kuncoro; Diana Kurnia Apriani; Nisa Naspiah; Agung Rahmadani
JURNAL FARMASI DAN MAKANAN Vol 5 No 2 (2022): Journal Of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v5i2.2345

Abstract

Kokang (L. amoena (Hassk) Leenh.) merupakan tanaman lokal Kalimantan Timur dan digunakan sebagai alternatif pengobatan oleh suku dayak untuk mengatasi berbagai masalah kulit, diantaranya menghilangkan noda hitam di wajah, menyembuhkan bekas luka cacar, bekas jerawat dan perawatan kulit (skincare). Penelitian ini bertujuan untuk memperoleh isolat senyawa metabolit sekunder yang memiliki aktivitas antioksidan dan mengetahui struktur kimia dari isolat tersebut. Metode yang digunakan adalah ekstraksi secara maserasi dengan metanol. Ekstrak difraksinasi dengan n-heksan, etil asetat dan n-butanol. Fraksi etil asetat diisolasi dengan menggunakan berbagai teknik kromatografi. Pengujian antioksidan menggunakan metode kualitatif dengan DPPH. Hasil isolasi didapatkan isolat EA31 yang memiliki aktivitas antioksidan. Hasil elusidasi struktur isolat berdasarkan MS, 1H-NMR dan 13C-NMR. diperoleh senyawa dengan rumus molekul C15H12O11 yang meberikan aktifitas terdapat radikal bebas DPPH.
Standarisasi Ekstrak Umbi Bawang Tiwai (Eleutherine americana (Aubl.) Merr.) Asal Kalimantan Timur Aditya Fridayanti; Yurika Sastyarina; Herman Herman; Agung Rahmadani; Ganjar Firmansyah; Tri Woro Widyanti; Yuspian Nur; Hadi Kuncoro; Enggar Wijayanti
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 6 (2017): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (239.04 KB) | DOI: 10.25026/mpc.v6i1.264

Abstract

Telah dilakukan standarisasi pada ekstrak etanol umbi bawang tiwai (Eleutherine americana (Aubl.). Merr). Hasil pengujian parameter spesifik menunjukkan organoleptik ekstrak kental, berwarna merah, tidak berbau dan memiliki rasa sedikit pahit, dengan kandungan senyawa larut air 25,36 ± 1,61 (%) dan senyawa larut etanol 11,52±1,87 (%) serta hasil kandungan senyawa marker ekstrak 0,002/g. Hasil pengujian parameter non spesifik ekstrak etanol 96% umbi bawang tiwai menunjukkan kadar abu total 0,90±0,35 (%), kadar abu tidak larut asam 0,78±0,25 (%), bobot jenis 0,9437±0,0012, kadar air 5,28±0,14%, sisa pelarut 1,019345±0,0001626% dan kadar fenol total 163,43 ppm. Pada ekstrak terdapat cemaran bakteri 3,5 x 104 koloni/gram dan cemaran kapang khamir sejumlah 3,0 x 103 koloni/gram. Pengujian cemaran logam berat diperoleh kadar timbal 0,0105 mg/mL, kadmium 0,0318 mg/L dan arsen 0,0412 mg/L. Pengujian residu pestisida negatif pada golongan klorin, organo fosfat dan karbamat. Hasil penelitian menunjukkan bahwa ekstrak memenuhi persyaratan umum obat yang dibuat oleh bahan alam
Karakteristik dan Penggunaan Antibiotik Pasien Sepsis di Rumah Sakit Abdul Wahab Sjahranie Periode 2017 Diana Anugrah Lestari; Viriyinata Wijaya; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (182.981 KB) | DOI: 10.25026/mpc.v7i1.283

Abstract

Sepsis merupakan kondisi medis yang ditandai dengan adanya peradangan di seluruh tubuh sebagai respon terhadap infeksi yang disebabkan oleh keadaan SIRS (Systemic Inflammatory Response Syndrome). Untuk menunjang terapi keberhasilan pengobatan penyakit sepsis digunakan terapi antibiotik. Dalam pemilihan antibiotik perlu diperhatikan beberapa hal guna menghindari resistensi dan resiko mortalitas. Penelitian ini bertujuan untuk mengetahui karakteristik dan penggunaan antibiotik pada pasien sepsis di Rumah Sakit Abdul Wahab Sjahranie. Metode penelitian yang digunakan adalah studi non eksperimental dengan rancangan deskriptif. Pengambilan data dilakukan secara retrospektif dengan subjek dari data rekam medik pasien sepsis di Rumah Sakit Abdul Wahab Sjahranie. Hasil penelitian menunjukkan bahwa penderita sepsis tertinggi berdasarkan jenis kelamin adalah perempuan (55%), berdasarkan usia adalah kelompok usia 45-64 tahun (73,33%), berdasarkan pekerjaan adalah ibu rumah tangga (36,66%) dan berdasarkan ruang rawat inap adalah ruang rawat kelas III (60%). Sebanyak 40% subjek penelitian menggunakan antibiotik tunggal dan 60% menggunakan antibiotik kombinasi.
Evaluasi Penggunaan Antibiotik pada Pasien Gonore Di RSUD AWS Samarinda Berdasarkan ATC/DDD dan DU90% Fatmawati Eka Putri; Febrina Mahmudah; Hadi Kuncoro
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 7 (2018): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (572.396 KB) | DOI: 10.25026/mpc.v7i1.284

Abstract

Gonore merupakan penyakit menular seksual yang disebakan oleh bakteri Neisseria gonorrhoeae yang dapat diobati dengan antibiotik. Penelitian ini bertujuan untuk mengetahui gambaran dan kuantitas penggunaan antibiotik pada penyakit gonore. Penelitian ini merupakan penelitian deskriptif dengan studi retrospektif yang diambil dari catatan medik untuk menilai kuantitas dan kualitas penggunaan antibiotik. Sampel diambil dengan cara total sampling. Hasil penelitian menunjukkan bahwa dari 66 catatan medik didapatkan total penggunaan antibiotik 54,33 DDD/1000 KPRJ dan antibiotik yang masuk dalam DU 90% yaitu cefixime (28,8 DDD/1000 KPRJ), azitromisin (14,1 DDD/1000 KPRJ), amoxicillin (3,2 DDD/1000 KPRJ), doxycycline (3,2 DDD/1000 KPRJ), levofloxacine (2,12DDD/1000 KPRJ), ciprofloxacin (1,7 DDD/1000 KPRJ), dan gentamisin (0,7DDD/1000 KPRJ). Kesimpulan penelitian yang didapat menunjukkan bahwa secara kuantitas penggunaan antibiotik yang paling banyak adalah cefixime sebesar 28,8DDD/1000 KPRJ.
Co-Authors Abdul Mun’im Aditya Fridayanti Afif Ruchaemi Aji Yudha Wijaya Ali Sadikin Alida Adelia Islami Amir, Muhammad Angga Cipta Narsa Aprilia Putri Firdaus Arsyik Ibrahim Aty Widyawaruyanti Azminah Azminah Bayu Tri Andika Crissty Magglin Daryono Devitamara Ayu Devitha Farah Mahdiyah Dewi Mayasari Dewi Rahmawati Diana Kurnia Apriani Diana Lestari Dwinita Aquastini Emma Susilowati Shabir Enggar Wijayanti Erwin Samsul Erwin Samsul Euis Julaeha Fahriani Istiqamah Jafar Fajar Prasetya Fajar Prasetya Falencia Ega Aprillia Fatmawati Eka Putri Febrina Mahmudah Fikriah, Ika Ganjar Firmansyah Gemini Alam Hajrah Hajrah Herman Herman Ika Rahayu Islamudin Ahmad Iswahyudi Iswahyudi Khemasili Kosala Kindi Farabi Laode Rijai Lisna Meylina Lizma Febrina Lutfiatun Nisak M Arifuddin M. Arifuddin Mahfuzun Bone Mira Susanti Mirhansyah Ardana Muhammad Akbar MUHAMMAD AMIR MASRUHIM Mukti Priastomo Nadia Rahma Kusuma Dewi Nadiyah Amalia Aprilliani Ni Made Mela Santi Nisa Naspiah Noor Erma Sugijanto Noor Linda Febrianie Novia Anggraini Novita Eka Kartab Putri Nur Masyithah Nurul Fitriani Oktaviany Triana Rahmadani, Agung Rahmi Annisa Riama Rita Manullang Risna Agustina Risna Agustina Rolan Rusli Rosanti Wahyu Saputri Rusmini Rusmini Satriani Badawi Siti Anisah Nur Fajriyati Sukartiningsih Sukartiningsih Suparningtyas, Juniza Firdha Supriatno Salam Syarifah Irhamnah Taslim Ersam Tri Woro Widyanti Unang Supratman Viriyinata Wijaya Wanda Millenia Alwie Welinda Ayu Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Yoshihito Shiono Yurika Sastyarina Yuspian Nur