SINTESIS DAN UJI TOKSISITAS SENYAWA 1-(2,4-DIKLOROFENIL)-3-(3,4-DIMETOKSIFENIL)PROPENON

Husnul Khatimah (Laboratorium Penelitian dan Pengembangan Kefarmasiaan “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Agung Rahmadani (Laboratorium Penelitian dan Pengembangan Kefarmasiaan “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
M. Arifuddin (Laboratorium Penelitian dan Pengembangan Kefarmasiaan “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)
Rolan Rusli (Laboratorium Penelitian dan Pengembangan Kefarmasiaan “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia)

Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Vol 4 No 1 (2019): JIIS

Chalcone has been widely reported to have various activities such as cytotoxic, antioxidant, antibacterial, and others. Synthesis becames the right way to get chalcone because it can produce much yield of chalcone and can be varied in accordance with the desired structure. The compound of 1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)propenone was synthesized by conventional method for 6 hours using a 40% NaOH catalyst with a yield of 90.87%. The toxicity test of 1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)propanone was done by Brine Shrimp Lethality Test method (BSLT). The results of the test showed that the 1-(2,4-dichlorophenyl)-3- (3,4-dimethoxyphenyl)propenone has toxicity value LC50 613.05 ppm.