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All Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Husnul Khatimah
Laboratorium Penelitian dan Pengembangan Kefarmasiaan “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia
Medicine & Pharmacology

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SINTESIS DAN UJI TOKSISITAS SENYAWA 1-(2,4-DIKLOROFENIL)-3-(3,4-DIMETOKSIFENIL)PROPENON Husnul Khatimah; Agung Rahmadani; M. Arifuddin; Rolan Rusli
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 4 No 1 (2019): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.025 KB) | DOI: 10.36387/jiis.v4i1.266

Abstract

Chalcone has been widely reported to have various activities such as cytotoxic, antioxidant, antibacterial, and others. Synthesis becames the right way to get chalcone because it can produce much yield of chalcone and can be varied in accordance with the desired structure. The compound of 1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)propenone was synthesized by conventional method for 6 hours using a 40% NaOH catalyst with a yield of 90.87%. The toxicity test of 1-(2,4-dichlorophenyl)-3-(3,4-dimethoxyphenyl)propanone was done by Brine Shrimp Lethality Test method (BSLT). The results of the test showed that the 1-(2,4-dichlorophenyl)-3- (3,4-dimethoxyphenyl)propenone has toxicity value LC50 613.05 ppm.
Co-Authors M Arifuddin Rahmadani, Agung Rolan Rusli