This research aimed to describe the improvement of junior high school student’s learning outcomes after the implementation of interactive multimedia of blood circulation system. This research used a One-Group Pretest-Posttest Design that involved 58 students grade VIII MtsN 4 Sidoarjo. The results of the research showed that the results of the N-Gain grade VIII A students showed that 65,5% of students received a high category score. The N-Gain results of Grade VIII B students showed that 55,2% of students received high categorical scores. Based on the results of the research, it concluded that the interactive multimedia of blood circulation system can improve students’ learning outcomes. Keywords: learning media, interactive multimedia, learning outcomes.
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