Jurnal Ilmiah Berkala Sains dan Terapan Kimia
Vol 6, No 1 (2012)

SINTESIS 3,3'-DI(5-BROMO-N-METILINDOL-3-IL)-5-BROMOINDOLIN-2-ONA DAN UJI SITOTOKSISITASNYA TERHADAP SEL VERO

Kamilia Mustikasari (Unknown)
Mardi Santoso (Unknown)

Article Info

Publish Date
18 Oct 2016

Abstract

Telah berhasil disintesis senyawa trisindolina baru: 3,3'-di(5-bromo-N- metilindol-3-il)-5-bromoindolin-2-ona melalui reaksi substitusi aromatik elektrofilik 5-bromo-N-metilindola dengan 5-bromoisatin pada kondisi asam dengan rendemen 53% yang tidak sitotoksik terhadap sel normal (sel Vero). Metilasi 5-bromoindola menghasilkan 5-bromo-N-metilindola dengan rendemen 87%. Kata kunci: sintesis, turunan 3,3'-di(indol-3-il)indolin-2-ona, sitotoksisitas 

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Journal Info
Jurnal Ilmiah Berkala Sains dan Terapan Kimia
Website

Abbrev

JSTK

Publisher

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat

Subject

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry

Description

Jurnal Ilmiah Berkala Sains dan Terapan Kimia is a peer-reviewed and open-access scientific journal published by the Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat. The journal publishes high-quality original research articles, review articles, ...