Cytotoxic Steroids from The Stem Bark of Chisocheton cumingianus (Meliaceae)

Dewa Gede Katja (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sam Ratulangi University, Kampus Kleak, Manado, 95115, North Sulawesi, Indonesia)
Kindi Farabi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia)
Nurlelasari Nurlelasari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Desi Harneti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Euis Julaeha (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Ace Tatang Hidayat (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Tri Mayanti (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Rani Maharani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Unang Supratman (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Indonesia)
Khalijah Awang (Departement of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 59100, Malaysia)

Molekul: Jurnal Ilmiah Kimia
Vol 12, No 1 (2017)

Three cytotoxic steroids, stigmasterol (1), stigmast-5-en-3b-ol (2) and b-sitosterol-3-O-acetate (3) were isolated from the stem bark of Chisocheton cumingianus. The chemical structures of those compounds were identified based on spectroscopic data and by comparison with those data previously reported. All of the compounds isolated were evaluated for their cytotoxic effects against P-388 murine leukemia cells in vitro. Compounds 1-3 showed cytotoxicity activity against P-388 murine leukemia cells with IC50values of 12.4, 60.8, and ˃ 100 mg/mL, respectively.