<![CDATA[Introduction: High-fat diet (HFD) may lead to hyperlipidemic condition increasing the risk of atherosclerosis. Jati belanda, kemuning, murbei and bangle (JKMB) contain active compounds such as flavonoid, saponin, tannin, and triterpenoid which empirically used as antihyperlipidemia. This study aim to examine the effect of JKMB water extract combination on serum level of LDL and HDL in male wistar rats receiving high fat diet (HFD).Methods: Experimental laboratory, in vivo with control group post test only design. Twenty five male wistar rats were divided into 5 groups namely: a negative control (KN), a positive control (KP), and three treated groups (D1, D2, D3). The groups of KP, D1, D2, D3 treated with HFD for 12 weeks. The groups of D1, D2, D3 simultaneously received doses of 189 mg/200gBB, 378 mg/200gBB, and 756 mg/200gBB respectively everyday for 12 weeks peroral. Serum level of LDL and HDL were measured by homogeneous enzymatic colorimetric assay. Data HDLwere statistically analyzed with One-way ANOVA followed by Least Significant Difference (LSD) test. Data LDL were statistically analyzed with kruskall walis test followed by mann whitney test.Results: Levels of LDL in the KP group was higher than KN group (p<0,05). LDL dose group 378 mg / 200gBB and 756 mg / 200gBB lower than the KP group but not significant (p> 0.05) The levels of HDL in the KP group was lower than the KN group, but not significantly (p>0,05). All the doses of the given water extract JKMB did not significantly increase HDL (p>0,05).Conclusion: Administration of JKMB infusion has no effect on LDL reduction and HDL increase in HFD-treated mice.]]>
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