Pharmaceutical Sciences and Research (PSR)
Vol. 5, No. 2

Potensi Anthelmintik Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L.) pada Cacing Ascaridia galli dan Raillietina tetragona secara In Vitro

Robiyanto, Robiyanto (Unknown)
Kusuma, Ria (Unknown)
Untari, Eka Kartika (Unknown)



Article Info

Publish Date
30 Aug 2018

Abstract

Arumanis mango (Mangifera indica L.), a medicinal plant, is allegedly potential as an anthelmintic agent. This research aimed to investigate the in vitro anthelmintic activity of ethanolic extract of arumanis mango leaves against Ascaridia galli and Raillietina tetragona; know the effect of increasing extract concentration; and calculate the LC50 and LT50 value of the extract. The extract concentrations tested were 5, 25 and 50 (mg/ml) with normal control (NaCl 0,9%) and positive control (mebendazole 5 mg/ml). The time and number of worm deaths were observed and analyzed statistically using One Way Anova SPSS, Post hoc (LSD) and Probit. The results showed that ethanolic extract had anthelmintic activity in which concentration of extract at 25 mg/ml and 50 mg/ml had death time and number of death worms similar to mebendazole 5 mg/ml for A. galli (p=0.466 and p=0.760) and R. tetragona (p=0.093 and p=0.566); the increasing of extract concentration was linear with the increase of its anthelmintic activity; and LC50 dan LT50 value of the extract for A. galli were 2,6 mg/ml and 15,2 hours, while for R. tetragona were 3,1 mg/ml and 2,5 hours. As a conclusion, arumanis mango leaves is potential to be developed as an anthelmintic traditional medicine.

Copyrights © 2018






Journal Info

Abbrev

publication:psr

Publisher

Subject

Description

Aims Pharmaceutical Sciences and Research (PSR), an international, peer-reviewed, open access, and official journal from Faculty of Pharmacy, Universitas Indonesia, aims to disseminate research results and findings in Pharmaceutical Sciences and Practices. Major area of interest is natural products ...