Diagnosis of cancer in children can be extremely stressful for the caregiver. The caregiver is “hidden patients” who have suffered from physical and psychological problems. However, only a few programs address the needs caregivers of children with cancer. This research aims to enhance psychological well-being (PWB) using mindfulness-based intervention for the caregiver. Participants of this study are 6 caregivers of children with cancer in Yayasan Kanker Anak Yogyakarta. The research design is one group of pretest-postest design. PWB scale used to measure caregiver’s well-being, given before treatment as a pre-test and after treatments as post-test. The descriptive statistic using Wilcoxon matched-pairs signed-ranks test showed improvements in psychological well being’s caregiver but were not statistically significant (Z= -1.051, p= 0.293 (p>0.05). However, caregivers had improved in self acceptance after mindfulness program (Z= -2.207, p= 0.016 (p< 0.05).
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