The aims of the study are to find out the effect of entrepreneurship knowledge and motivation on business successs through self-efficacy on msmes activities in the city of jember. This study uses quantitative research Method. The result shows that Entrepreneurial knowledge and motivation had a direct effect on business successs by 0.343 and 0.419., Entrepreneurial knowledge had indirect effect on business success through self-efficacy by 0.011 so the total effect was 0,354. Motivation has an indirect effect on business success through self-efficacy by 0.062 so the total effect was 0,481.
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