Jurnal Sains dan Teknologi Farmasi
Vol 17 No 1 (2012)

Uji Efek Antipiretik Ekstrak Etanol, Fraksi N-Heksana dan Fraksi Etil Asetat Daun Beringin (Ficus Benjamina L.) pada Tikus Putih Jantan (Rattus Norvegicus)

Hasti, Syilfia (Unknown)
Sandi, Nofri Hendri (Unknown)
Srianti, Teti (Unknown)



Article Info

Publish Date
30 Mar 2017

Abstract

Banyan plant has been used by communities as a traditional medicine in order to heal heat cramps in children but it has not been scientifically tested. A study has been conducted to observe an antipyretic effect of the ethanolic extract, the fraction of n-hexane and ethyl acetate fraction of the leaves of banyan (Ficus benjamina. L) in male white rats (Rattus norvegicus) with fever induction method using a solution of peptone 2% as much as 0.5 mL / 200 g body weigt intra peritonially, with the dose of ethanol extract, the fraction of n-hexane and ethyl acetate fractions 100, 200, and 400 mg / kg orally. Respectively as a positive control, asetosal was administered at a dose 117 mg / kg and the negative control was 1% CMC Na. Temperature observations of mice performed at 30, 60, 90, 120, 150, and 180 minutes, then percent protection was calculated. Data analysis was done using Two-way Analysis of Variance (ANOVA) and Tukey test. Results showed that the fraction of n-hexane at a dose of 400 mg/kg had an antipyretic effect as significantly (p<0.05).

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