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All Journal Jurnal Penelitian Farmasi Indonesia Jurnal Sains dan Teknologi Farmasi Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional JFIOnline Jurnal Ners JPK: Jurnal Proteksi Kesehatan INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Nofri Hendri Sandi
Sekolah Tinggi Ilmu Farmasi Riau
Computer Science & IT Decision Sciences, Operations Research & Management Education Health Professions Medicine & Pharmacology Nursing Public Health

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Pengaruh Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K Schum) Terhadap Klirens Kreatinin Mencit Putih (Mus musculus L.) Jantan Susanty, Adriani; Sandi, Nofri Hendri; M, Wewen Sista
Jurnal Penelitian Farmasi Indonesia Vol 1, No 2 (2013)
Publisher : Jurnal Penelitian Farmasi Indonesia

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Abstract

A research on effect of ethanol extract of tampa badak (Voacanga foetida) to renal function of male white mice at doses 100, 200 and300mg/kgBW of weight has been studied. The employed parameter was measuring creatinine clearence and the kidney weight ratio of malewhite mice in the 61st day. In this study, four group of male white mice, each of which consisted of five mice, were utilized. Three groups weregiven suspension of ethanol extract of tampa badak and the other group as a control was simply given suspension of NaCMC 1% orally. Themeasurement method used was the method of chemical reaction with using reagent Diasys and by using ultraviolet-visible spectrophotometry(Microlab 200) at wavelength 505 nm. The result showed that application of ethanol extract of tampa badak did not give significant effect(p>0,05) to 24 hour urine volume, urinary creatinie quantity, serum creatinine, cretinine clearance as well as kidney weight ratio of malewhite mice.
Uji Efek Antipiretik Ekstrak Etanol, Fraksi N-Heksana dan Fraksi Etil Asetat Daun Beringin (Ficus Benjamina L.) pada Tikus Putih Jantan (Rattus Norvegicus) Hasti, Syilfia; Sandi, Nofri Hendri; Srianti, Teti
Jurnal Sains dan Teknologi Farmasi Vol 17 No 1 (2012)
Publisher : Fakultas Farmasi Universitas Andalas

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Abstract

Banyan plant has been used by communities as a traditional medicine in order to heal heat cramps in children but it has not been scientifically tested. A study has been conducted to observe an antipyretic effect of the ethanolic extract, the fraction of n-hexane and ethyl acetate fraction of the leaves of banyan (Ficus benjamina. L) in male white rats (Rattus norvegicus) with fever induction method using a solution of peptone 2% as much as 0.5 mL / 200 g body weigt intra peritonially, with the dose of ethanol extract, the fraction of n-hexane and ethyl acetate fractions 100, 200, and 400 mg / kg orally. Respectively as a positive control, asetosal was administered at a dose 117 mg / kg and the negative control was 1% CMC Na. Temperature observations of mice performed at 30, 60, 90, 120, 150, and 180 minutes, then percent protection was calculated. Data analysis was done using Two-way Analysis of Variance (ANOVA) and Tukey test. Results showed that the fraction of n-hexane at a dose of 400 mg/kg had an antipyretic effect as significantly (p<0.05).
Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

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Abstract

Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
Uji Aktivitas Antidiabetes Ekstrak Etanol dari Akar dan Batang Tumbuhan Sekunyit (Fibraurea Tinctoria Lour) Utami, Rahayu; Sandi, Nofri Hendri; Hasti, Syilfia; Delvia, Sutri
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.003 KB) | DOI: 10.35617/jfi.v7i4.198

Abstract

Sekunyit (Fibraurea tinctoria Lour) is a species plant that has been used as traditional medicine for treating several diseases including jaundice, dysentery, headache, eye infection as well as anti diabetic drug. This research aims to evaluate antidiabetic activity of ethanol extract of roots and stem of sekunyit on white male mice (Mus musculus L) using glibenclamide as positive control. The experimental animals were induced with alloxan 175 mg/Kg BW i.p and devided into six groups, each group consisted of five mice. Group one served as negative control which was given NaCMC 1%, group second was positive control, given  glibenclamide 0,65 mg/KgBW, while group third, fourth, fifth were administered orally with etanol extract with doses of 100, 200 and 300 mg/KgBW, respectively. The observed parameter were measurement of blood glucose levels, urine volume and volume of drinking water as well as ratio of relative organ weight. The treatment was conducted for 15 days. The result showed that administration of ethanol extract of roots and stem of sekunyit can lowered significantly blood glucose levels (p<0,05) of alloxan induced-diabetic mice, decreased urine volume (p<0,05), decreased volume of drinking water (p<0,05), and did not affect relative organ weight of heart, liver and kidney (p>0,05).
AKTIVITAS INHIBISI ENZIM ALFA-GLUKOSIDASE DARI EKSTRAK KULIT BATANG BUNGA KUPU-KUPU (Bauhinia semibifida Roxb) SECARA IN VITRO Haiyul Fadhli; Nofri Hendri Sandi; Ainun Nurain Nurdin
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (478.201 KB) | DOI: 10.36387/jiis.v6i2.701

Abstract

Research on the activity of ?-glucosidase inhibition of Bunga Kupu-Kupu stem bark extract (Bauhinia semibifida Roxb) has been carried out in vitro. This study aims to determine the inhibitory activity of the extracts of B. semibifida Roxb. stem bark against the ?-glucosidase enzyme in vitro. Testing the inhibitory activity of the ?-glucosidase enzyme using extracts of n-hexane, ethyl acetate, and methanol from the stem bark of the Bunga Kupu-Kupu and the Akarbose as a positive control. In vitro testing was carried out using a microplate reader instrument with a wavelength of 410 nm. The results showed that the extract of n-hexane extract of the B. semibifida stem bark had an IC50 value 15,625 µg/mL, ethyl acetate extract had an IC50 value 35,495 µg/mL, and the methanol extract had an IC50 value 34,279 µg/mL. By category, the three B. semibifida stem bark extracts have the active ability to inhibit the ?-glucosidase enzyme, while the Akarbose had an IC50 value 0,384 µg/mL as a positive control has a very active ability as an antidiabetic through the inhibition of the ?-glucosidase enzyme. The results showed that extraction of ?-glucosidase inhibitor compound with n-hexane yielded extract with highest inhibitor activity.
Sosialisasi pencegahan dan pengendalian Infeksi Saluran Nafas Akut di Wilayah XIII Koto Kampar Rahmayati Rusnedy; Adriani Susanty; Rickha Octavia; Nofri Hendri Sandi; Ferdy Firmansyah; Armon Fernando
INDRA: Jurnal Pengabdian kepada Masyarakat Vol. 1 No. 2 (2020): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.702 KB) | DOI: 10.29303/indra.v1i2.28

Abstract

Acute Respiratory Infection (ARI) is one of the highest infectious diseases in Indonesia that can cause death. The public knowledge about the prevention and control of ARI is inadequate, so prevention efforts are needed to reduce the transmission of this infection disease. The purpose of this community service activity is to increase the knowledge of the people of Gunung Bungsu Village, Kec. XIII Koto Kampar on preventing the transmission of ARIs through preventive measures by providing education on how to use masks and proper ethics when coughing/sneezing. The method used was an interactive and participatory model by involving the community at Gunung Bungsu Village, Kec. XIII Koto Kampar. This socialization activity increased the community knowledge, showed by the enthusiasm of community at Gunung Bungsu Village, Kec. XIII Koto Kampar who actively interacts through the questions they ask to increase their understanding of ARI. Beside that, the results of the questionnaire assessment showed that the community was satisfy with the socialization of ARI prevention. This service can be useful for the prevention and control of ARI around the neighborhood.
The Antidiabetic Activity of Curcuma mangga Val. Rhizome Ethyl Acetate Fraction against Mice Induced by Alloxan Yan Hendrika; Nofri Hendri Sandi
JURNAL PROTEKSI KESEHATAN Vol 10 No 1 (2021): JPK: Jurnal Proteksi Kesehatan
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Poltekkes Kemenkes Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36929/jpk.v10i1.348

Abstract

The rhizome of the temu mangga is a member of the Zingiberaceae family that has been used since ancient times for treatment of diabetes. The aim of this study was to examine the activity of reducing blood glucose levels in diabetic mice induced by alloxan after administration of the ethyl acetate fraction of temu mangga rhizome at a dose of 100; 200 and 300 mg/KgBW were compared with negative control (Na CMC) and positive control (Glibenclamide 0.65 mg/Kg BW). The research data were statistically analyzed using two-way ANOVA for the parameters of the percentage decrease in blood glucose and the percentage change in body weight followed by the Tukey multiple range test. The results showed that the administration of the ethyl acetate fraction of the mangga rhizome at doses of 100, 200 and 300 mg/KgBW prevented weight loss in mice compared to negative controls (p<0.05). The decrease in blood glucose levels of mice that were given the ethyl acetate fraction of the temu mangga rhizome at doses of 100, 200 and 300 mg/KgBW showed a significant difference compared to the negative control, and the dose of 300 mg/KgBW showed an insignificant difference compared to the positive control. The activity of lowering blood glucose levels is thought to be influenced by the content of terpenoid compounds.
UJI EFEK ANALGETIK, TOKSISITAS AKUT DAN TERTUNDA EKSTRAK ETANOL DAUN BERINGIN (Ficus benjamina L.) PADA MENCIT PUTIH JANTAN (Mus musculus) Syilfia Hasti; Elka Yuslinda; Nofri Hendri Sandi; Wan Liawati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (56.119 KB) | DOI: 10.31942/jiffk.v0i0.376

Abstract

Salah satu tumbuhan yang telah digunakan oleh masyarakat sebagai obat tradisional yaitu daun beringin guna mengatasi rasa nyeri dan dari penelusuran pustaka belum ada dilakukan pengujian secara ilmiah begitu juga dengan penelitian tentang toksisitasnya. Berdasarkan hal tersebut, telah dilakukan penelitian untuk mengetahui efek analgetik ekstrak etanol daun beringin yang diberikan secara oral pada hewan coba mencit putih jantan yang diberi asam asetat 1% v/v sebanyak 0,1 ml sebagai penginduksi nyeri. Penelitian dilakukan menurut metode writhing test, menggunakan pembanding asetosal dengan dosis 65 mg/kgBB. Bahan uji diberikan secara oral dalam bentuk suspensi dalam Na CMC 1%, diberikan tiga puluh menit sebelum pemberian asam asetat. Pengamatan jumlah geliat dilakukan setelah penyuntikan asam asetat. Jumlah geliat dihitung dengan selang waktu 10 menit selama 90 menit kemudian dihitung persen proteksinya. Penelitian toksisitas akut (LD50) dihitung sebagai dosis yang memberikan kematian hewan sebanyak 50% dari jumlah hewan percobaan selama 24 jam setelah penyuntikan dan toksisitas tertunda dilakukan pada dosis 1000, 2000, 4000, 8000, dan 16000 mg/kgBB terhadap parameter volume air minum, volume urin, perubahan berat badan, konsumsi makanan, berat feses, rasio organ ginjal dan jantung. Hasil penelitian menunjukkan bahwa ekstrak etanol pada dosis 100, 200, dan 400 mg/kgBB memberikan efek analgetik p < 0,05 terhadap kontrol negatif (analisis varian dua arah dan analisis Tukey). Berdasarkan hasil pengujian toksisitas akut, ekstrak etanol daun beringin digolongkan praktis tidak toksik. Hasil penelitian yang menunjukkan adanya gejala toksisitas akut, ekstrak etanol daun beringin digolongkan praktis tidak toksik. Hasil penelitian yang menunjukkan adanya gejala toksisitas tertunda terhadap parameter perubahan berat badan, konsumsi makanan, berat feses, organ ginjal dan jantung signifikan pada dosis 16000 mg/kgBB.   Kata kunci : Analgetik, Ficus benjamina, writhing test.
Formulation of Microemulsion of Cayenne Pepper (Capsicum Frutescens L.) Ethanol Extract and Hair Growth Activity Test Anggraini, Deni; Sandi, Nofri Hendri; Djohari, Meiriza
Majalah Obat Tradisional Vol 29, No 2 (2024)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.87206

Abstract

Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery system through the scalp to stimulate hair growth. The microemulsion was made with olive oil and tween 80 as surfactants and stirred using a magnetic stirrer at 1000 rpm for 3 minutes. The ethanol extract of cayenne pepper was prepared in microemulsions at three different concentrations: 0.1%, 0.2%, and 0.3%. Microemulsion tests included organoleptic tests, specific gravity, pH, viscosity, freezing and thawing stability tests, and hair growth activity tests on rabbits. The results showed that the microemulsion of cayenne pepper ethanol extract at concentrations of 0.1%, 0.2%, and 0.3% was quite stable with a clear appearance and a particle size ranging from 27.7 nm to 167.8 nm. The microemulsion of cayenne pepper ethanol extract at a concentration of 0.2% was the most effective in enhancing hair growth, achieving a hair growth length of 1.27 over a 30-day period. A two-way ANOVA statistical test showed that the hair length of rabbits using microemulsion was significantly different from the hair length of negative control animals at p<0.05.
Aktivitas Antijamur Fraksi N-Heksana Kulit Buah Citrus sinensis (L.) Osbeck Melzi Octaviani; Wiwin Suryani; Nofri Hendri Sandi
Jurnal Ilmu Farmasi dan Farmasi Klinik No 1 (2024): JIFFK Special Edition Suppl. 2
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v2i1.9991

Abstract

The sweet orange (Citrus sinensis (L.) Osbeck) is a fruit that is loved by all walks of life because of its sweet taste. The flesh part of the fruit is consumed, while the fruit peel is discarded. However, the fruit peel also contains secondary metabolites, which have various biological activities. The peel of this sweet orange fruit contains secondary metabolites of alkaloids, flavonoids, phenolics, steroids, and terpenoids. This study aims to determine the antifungal activity of the n-hexane fraction against Trichophyton mentagrophytes and Candida albicans using the disc diffusion method and the Minimum Inhibitory Concentration (MIC). The results of measuring the diameter of the inhibition zone formed on the fungus Trichophyton mentagrophytes at a concentration of 50; 25; 12.5; 6.25; 3.125 and 1.5625% w/v, respectively 12.29±0.08; 11.14±0.12; 9.54±0.17; 7.01±0.12; 6.19±0.03; 6.06 ± 0.03 mm, with a MIC of 1.5625 %. Results of measuring the diameter of the inhibition zone formed against Candida albicans fungi respectively 9.97 ± 0.02; 9.05±0.18; 8.32±0.38; 7.09±0.07; 6.00±0.00; 6.00±0.00 mm, with a MIC of 6.25%. The results of data analysis using one-way ANOVA statistics showed that there was a significant difference (p<0.05) between variations in the concentration of the test fraction with positive control and negative control. Based on the research that has been carried out, it can be concluded that the n-hexane fraction of sweet orange peel has activity in inhibiting the growth of the test fungus, with the best antibacterial activity at a concentration of 50% w/v.
Co-Authors Adriani Susanty Ainun Nurain Nurdin Aisyah, Hanifah Siti Alpatiqa, Siti Hizra Armon Fernando Delvia, Sutri Delvia, Sutri Deni Anggraini Elka Yuslinda Ferdy Firmansyah Haiyul Fadhli Meiriza Djohari, Meiriza Melzi Octaviani Mira Febrina, Mira Rahayu Utami Riani, Siti Rickha Octavia Rusnedy, Rahmayati Syilfia Hasti Teti Srianti Wan Liawati Wewen Sista M Wiwin Suryani Yan Hendrika