<![CDATA[This study aims to design and produce Student Activity Sheets based on Science Technology Engineering and Mathematics (STEM) on Virus material. The research design used is a type of research and development. The subjects in this study were Material Experts, Media Experts, Instrument Experts, Biology teachers and students of class X-IPA-2 MAS-AL-Washliyah 12 Perbaungan. Data collection was carried out with instruments in the form of material expert validation assessment sheets, media experts, teacher assessment instrument experts and student responses. Data analysis used quantitative and qualitative descriptive analysis. The design of STEM-based student worksheets is carried out using the 4D development model because in this model each stage is revised until a better student worksheet product is obtained. The results showed that the design of STEM-based student worksheets based on the assessment of material experts obtained an average percentage of 98.2 % with very valid criteria, the assessment of media experts obtained an average percentage of 84 % with very valid criteria, and the assessment of instrument experts obtained an average percentage 100 % with very valid criteria. The results of using student worksheets based on the STEM approach designed to foster scientific literacy skills obtained an average score of 8.6.3 % with a total of 19 students who completed. STEM-based student worksheets on Virus material that have been designed to obtain the assessment criteria of "Very Practical " and have fulfilled the requirements for effective use in improving scientific literacy skills and are suitable for use in the Biology learning process on virus material]]>
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