Makara Journal of Science
Vol. 18, No. 2

Detection of Papua New Guinea Thalassemia Alpha Mutation in Gayo, Sumba, Ternate, and Timika Populations

Nurfitriani, Risya (Unknown)
Abinawanto, Abinawanto (Unknown)
Noviyanti, Rintis (Unknown)
Trianti, Lely (Unknown)
Nainggolan, Ita M. (Unknown)

Article Info

Publish Date
25 Jun 2014

Abstract

Papua New Guinea (PNG) mutation is a point mutation that occurs in noncoding region of alpha globin clusters. Polymorphism promotes an additional recognition site for transcription factor (GATA-1) which presumably downregulates alpha globin synthesis. The aim of this research is to detect PNG mutation in other populations in Indonesia, thus the results will be used for completing standard diagnoses in detecting alpha thalassemia mutation based on ethnic background. The method used in detecting PNG mutation was PCR-RFLP. Detection of 399 samples (MCH

Copyrights © 2014




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Journal Info
Makara Journal of Science
Website

Abbrev

publication:science

Publisher

Universitas Indonesia

Subject

Description

Makara Journal of Science publishes original research or theoretical papers, notes, and minireviews on new knowledge and research or research applications on current issues in basic sciences, namely: Material Sciences (including: physics, biology, and chemistry); Biochemistry, Genetics, and ...