Laporan Kasus Berbasis Bukti: Akurasi Diagnostik RT-PCR Spesimen Saliva terhadap Spesimen Swab Nasofaring pada Suspek COVID-19

Jason Theola (Fakultas Kedokteran, Universitas Indonesia, Salemba, Jakarta, Indonesia)
Ananda Maulana Fanshur (Fakultas Kedokteran, Universitas Indonesia, Salemba, Jakarta, Indonesia)
Muhammad Rayyan Faher Shahab (Fakultas Kedokteran, Universitas Indonesia, Salemba, Jakarta, Indonesia)
Nico Gamalliel (Fakultas Kedokteran, Universitas Indonesia, Salemba, Jakarta, Indonesia)

Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
Vol 71 No 6 (2021): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo

Introduction: Nasopharyngeal swab followed by RT-PCR has become the gold standard in diagnosing COVID-19. This method is difficult to perform because the procedure is inconvenient for the patient. There is another diagnostic method using saliva as an RT-PCR specimen.Objective: To determine the diagnostic accuracy of saliva specimen RT-PCR in diagnosing COVID-19 compared to nasopharyngeal swab specimens as the gold standard.Methods: Literature searching was performed by searching literature through MEDLINE, EBSCO, and Scopus. The articles selected were diagnostic or cross-sectional studies containing sensitivity, specificity, prevalence data, and appropriate to our PICO and eligibility criteria. A critical appraisal was performed after obtaining the selected articles.Results: Six articles were critically appraised. All articles showed that the saliva sample used for RT-PCR in diagnosing COVID-19 had good diagnostic accuracy.Conclusion: Saliva specimen to diagnose COVID-19 can replace nasopharyngeal swab specimen because it has comparable diagnostic accuracy with the gold standard. It is also a non invasive method which is more convenient for patients.