Jurnal Insan Farmasi Indonesia
Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia

Uji Aktivitas Antelmintik Ekstrak Etanol Kulit Batang Sengkuang Dracontomelon dao (Blume) Merr. & Rofle Terhadap Cacing Gelang Ayam (Ascaridia gallu) Secara In Vitro

Inderiyani Inderiyani (Akademi Yarsi Pontianak)
Heny Puspasari (Akademi Farmasi Yarsi Pontianak)
Risma Wahyu Architasari (Akademi Farmasi Yarsi Pontianak)



Article Info

Publish Date
31 May 2023

Abstract

Worms are diseases caused by worms that need serious treatment. Sengkuang Dracontomelon dao (Blume) Merr & Rofle has the potential as an alternative worm treatment because it contains secondary metabolites i.e. alkaloids, saponins, tannins, flavonoids and triterpenoids which have activity as anthelmintics. This study aims to determine the activity, LC50 and LT50 values ​​of sengkuang stem bark as an anthelmintic against Ascaridia galli in vitro. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test the anthelmintic activity by incorporating 5 chicken roundworms into each test solution, 0,9% NaCl (negative control), 0,5% mebendazole (positive control), ethanol extract of sengkuang stem bark 0,2%; 0,4%, and 0,6%. Incubated at 37°C and observed the time of paralysis, the time and number of worm deaths every 1 hour for 24 hours. The results showed that the ethanol extract of sengkuang bark at concentrations of 0,2%; 0,4% and 0,6% had anthelmintic activity with a mortality rate of 100%, an LC50 value is 0,13% and an LT50 value respectively is 15,67 hours; 10,83 hours and 7,85 hours.

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Journal Info

Abbrev

JIFI

Publisher

Subject

Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Physics

Description

Focus and Scope Jurnal Insan Farmasi Indonesia (JIFI) is a broad-based primary journal covering all branches of pharmacy and its sub-disciplines that contains complete research articles, short communication and review articles. JIFI is a forum for the publication of quality and original works that ...