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UJI AKTIVITAS ANTIDIARE EKSTRAK ETANOL KULIT BATANG SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe TERHADAP MENCIT PUTIH (Mus musculus) JANTAN DENGAN METODE PROTEKSI DIARE Inderiyani Inderiyani; Sulastri Sulastri
Jurnal Insan Farmasi Indonesia Vol 4 No 2 (2021): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v4i2.825

Sengkuang Dracontomelon dao (Blanco) Merr & Rolfe is a plant that has secondary metabolites tannins and flavonoids which are thought to have anti-diarrheal activity. The purpose of this study to determine activity and dose of ethanol extract of the stem bark of Dracontomelon dao (Blanco) Merr & Rolfe which has antidiarrheal effect on male white mice (Mus musculus). The antidiarrheal activity test was using the diarrhea protection method, where mice were induced by 0.75 mL of oleum ricini orally, 1 hour later the test solution was given i.e. 0.5% Na CMC suspension (negative control), loperamid 0.26 mg/kg bw (positive control), dose of sengkuang stem bark ethanol extract 100 mg/kg bw, 200 mg/ kg bw and 300 mg/kg bw. Then observed the onset of diarrhea, frequency of diarrhea, consistency of diarrhea, duration of diarrhea and weight of diarrhea every 30 minutes for 4 hours. The results is the ethanol extract of the stem bark Dracontomelon dao (Blanco) Merr & Rolfe at a dose of 100 mg/kg bw, 200 mg/kg bw and 300 mg/kg bw has antidiarrheal activity as indicated by a significant difference in the test group (control positive and all extracts) against the negative control group (p <0.05).

Uji Aktivitas Antelmintik Ekstrak Etanol Kulit Batang Sengkuang Dracontomelon dao (Blume) Merr. & Rofle Terhadap Cacing Gelang Ayam (Ascaridia gallu) Secara In Vitro Inderiyani Inderiyani; Heny Puspasari; Risma Wahyu Architasari
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1357

Worms are diseases caused by worms that need serious treatment. Sengkuang Dracontomelon dao (Blume) Merr & Rofle has the potential as an alternative worm treatment because it contains secondary metabolites i.e. alkaloids, saponins, tannins, flavonoids and triterpenoids which have activity as anthelmintics. This study aims to determine the activity, LC50 and LT50 values of sengkuang stem bark as an anthelmintic against Ascaridia galli in vitro. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test the anthelmintic activity by incorporating 5 chicken roundworms into each test solution, 0,9% NaCl (negative control), 0,5% mebendazole (positive control), ethanol extract of sengkuang stem bark 0,2%; 0,4%, and 0,6%. Incubated at 37°C and observed the time of paralysis, the time and number of worm deaths every 1 hour for 24 hours. The results showed that the ethanol extract of sengkuang bark at concentrations of 0,2%; 0,4% and 0,6% had anthelmintic activity with a mortality rate of 100%, an LC50 value is 0,13% and an LT50 value respectively is 15,67 hours; 10,83 hours and 7,85 hours.

UJI AKTIVITAS ANTIPIRETIK EKSTRAK ETANOL UMBUT BATANG ROTAN (Calamus rotang L.) TERHADAP MENCIT PUTIH JANTAN (Mus musculus) Inderiyani Inderiyani; Sulastri Herdaningsih
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 1 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Rattan plant (Calamus rotang L.) is a plant that widely used by the people of Kapuas Hulu, West Kalimantan to treat diseases, as food and craft raw materials. Rattan plants contain flavonoids and alkaloids as secondary metabolites which are thought to have antipyretic activity. The purpose of this study was to determine the antipyretic activity of ethanol extracts of rattan stem umbut induced by 5% peptone. This research uses white mice (Mus musculus) male webster swiss strain as a test animal. The study was conducted using 5 test groups, the negative control group (aquadest), positive control (paracetamol 65 mg / KgBB), ethanol extract of rattan stem extract at a dose of 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB. Mice were induced with 5% peptone solution subcutaneously, then after an increase in rectal temperature ≥ 0.6◦C (fever) mice were treated with oral test solutions. The rectal temperature was measured using a digital thermometer in the 30th, 60th, 90th, 120th, 150th and 180th minutes. The results showed a group of ethanolic extracts of rattan stem at dose 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB had significant differences in the negative control group (p<0.05) with the percentage of antipyretic activity respectively at 117.17%; 154.76% and 226.19%. The conclusion of this research is the ethanol extract group of rattan stem extracts with a dose of 0.25 g / KgBB; 0.5 g / KgBB and 1 g / KgBB have antipyretic activity.

UJI AKTIVITAS DIURETIK EKSTRAK ETANOL UMBUT BATANG ROTAN (Calamus rotang L.) TERHADAP MENCIT PUTIH (Mus musculus) JANTAN GALUR SWISS WEBSTER Inderiyani Inderiyani
Jurnal Komunitas Farmasi Nasional Vol. 1 No. 2 (2021): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Diuretics are drugs that work on the kidneys to increase the excretion of water and sodium chloride. Diuretics are used to reduce edema in congestive heart failure, some kidney diseases, hepatic cirrhosis and hypertension therapy. One of the traditional medicinal plants that is thought to have diuretic activity is rattan (Calamus rotang L.). Rattan has secondary metabolites i.e. flavonoids, alkaloids and saponins where flavonoids have biological activity as a diuretic. The purpose of this study was to determine whether the ethanol extract of rattan stem (EEUMBR) has activity as a diuretic on male white mice (Mus musculus). They are 5 groups in this study i.e. group I as a negative control (Na.CMC 0.5%), group II as a positive control (furosemide 52 mg/kg bw), group III as EEUMBR group 0.25 g/kg bw, group IV as a group. group EEUMBR 0.5 g /kg bw and group V EEUMBR group 1 g/kg bw. Data obtained by observing the volume of urine excreted for 6 hours. Data showed that the amount of urine excreted in the EEUMBR group was greater than the negative control group i.e 1.39 mL (EEUMBR 0.25 g/kg bw), 1.47 mL (EEUMBR 0.25 g/kg bw), 1.69 mL (EEUMBR 0.25 g/kg bw) while the negative control group was 1.12 mL. The results of statistical analysis showed that the five experimental groups had significant differences with a sig value was 0.02 (p<0.05). Based on these data, it can be concluded that the ethanol extract of rattan stem umbut has activity as a diuretic.

UJI AKTIVITAS ANTIHIPERGLIKEMIA EKSTRAK ETANOL KULIT BATANG SENGKUANG Dracontomelon dao (Blanco) Merr & Rolfe TERHADAP MENCIT PUTIH (Mus musculus) JANTAN GALUR SWISS WEBSTER inderiyani inderiyani; Sulastri Herdaningsih; Ihsanul Arief Arief
Jurnal Komunitas Farmasi Nasional Vol. 2 No. 2 (2022): Jurnal Komunitas Farmasi Nasional
Publisher : Akademi Farmasi Yarsi Pontianak

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Diabetes mellitus (DM) is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Sengkuang Dracontomelon dao (Blanco) Merr & Rofle has the potential as an alternative treatment for DM because it contains secondary metabolites in the form of alkaloids, tannins and flavonoids which have antihyperglycemic properties. This study aims to determine the antihyperglycemic activity of sengkuang stem bark against male white mice. Sengkuang bark is processed into simplicia and then macerated using 96% ethanol as a solvent. Then the extract was used to test antihyperglycemic activity by measuring initial glucose levels with a glucose test strip and given a test solution in the form of 0.5% Na.CMC suspension; glibenclamide 65 mg/kgbb; ethanol extract of sengkuang stem bark dose of 100 mg/kgbb; 200 mg/kgbb and 400 mg/kgbb. Then the test animals were induced with glucose 75 gram/kgbb and blood glucose levels were measured at 0, 30, 60, 90, 120, 150 and 180 minutes. The results showed that the ethanol extract of sengkuang bark at a dose of 400 mg/kgbb had activity as antihyperglycemic indicated by a significant difference with the negative control group. Keywords : Antihyperglycemia, diabetes mellitus, ethanol extract of sengkuang bark, Dracontomelon dao (Blanco) Merr & Rofle

POTENSI INTERAKSI OBAT-OBAT POLIFARMASI PADA PASIEN GERIATRI: STUDI RETROSPEKTIF DI SALAH SATU APOTEK KOTA PONTIANAK Herdaningsih, Sulastri; Inderiyani, Inderiyani; Fauzan, Suhaimi; Hairunnisa, Hairunnisa; Aulia, Gina; Asmara, Ratna Dewi Lintang
Edu Masda Journal Vol 7, No 1 (2023): Edu Masda Journal Volume 7 Nomor 1
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v7i1.185

Drug-drug interactions are changes in the effectiveness or toxicity of one drug due to the presence of other drugs that are given simultaneously. These drug interactions can cause several problems, including decreased therapeutic effect, increased toxicity, or unexpected pharmacological effects. The purpose of this study was to determine the potential for drug-drug interactions in geriatric patients in a retrospective study and to determine the percentage of potential drug-drug interactions in geriatric patients in a retrospective study at a Pontianak City Pharmacy. This research method was carried out in a retrospective way, namely research conducted from January 2022 to March 2022 with inclusion criteria and exclusion criteria. Data is processed through the www.drugs.com database or Drug Interactions Checker. Of the total prescriptions that have been analyzed, there is a percentage of potential drug interactions of 9.76% consisting of major 11.72%, moderate 64.06% and minor 24.22%. From this study it is known that moderate drug interactions are higher than major and minor interactions, so the use of polypharmacy drugs in geriatric patients must be watched out so as not to cause a decrease in the patient's clinical status.ABSTRAKInteraksi obat-obat merupakan perubahan efektivitas atau toksisitas satu obat karena adanya obat lain yang diberikan secara bersamaan. Interaksi obat ini dapat menyebabkan beberapa masalah antara lain penurunan efek terapi, peningkatan toksisitas, atau efek farmakologis yang tidak diharapkan. Tujuan dari penelitian ini adalah untuk mengetahui adanya potensi interaksi obat dengan obat pada pasien geriatri studi rektrospektif dan untuk mengetahui berapa persentase potensi kejadian interaksi obat dengan obat pada pasien geriatri studi rektrospektif disalah satu Apotek kota Pontianak. Metode penelitian ini dilakukan dengan cara rektrospektif yaitu penelitian yang dilakukan pada bulan januari 2022 sampai maret 2022 dengan kriteria inklusi dan kriteria eksklusi. Data diproses melalui www.drugs.com database atau Drug Interactions Checker. Dari total resep yang telah dianalisis terdapat persentase potensi interaksi obat sebesar 9,76% yang terdiri dari mayor 11,72%, moderat 64,06 %, dan minor 24,22 %. Dari penelitian ini diketahui bahwa interaksi obat moderat lebih tinggi dibandingan dengan interaksi mayor dan minor, sehingga penggunaan obat polifarmasi pada pasien geriatri harus diwaspadai agar tidak menyebabkan penurunan status klinis pasien.

UJI AKTIVITAS ANTIDIARE INFUSA KACANG PANJANG (Vigna sinensis L.) TERHADAP MENCIT PUTIH (Mus musculus) JANTAN Inderiyani, Inderiyani; Herdaningsih, Sulastri; Pramana, Yoga; Olivia
Jurnal Insan Farmasi Indonesia Vol 7 No 1 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v7i1.1761

Diarrhea is a disorder of defecation more than 3 times a day with a liquid stool consistency, which may be accompanied by blood and/or mucus. This plant has the potential to be used as an alternative treatment for diarrhea, one of which is cowpea (Vigna sinensis L.). Cowpea is a plant that has secondary metabolites in the form of flavonoids, sterols and tannins which are thought to have activity as antidiarrheal. This study aims to determine the activity and dose of cowpea as antidiarrheal against male white mice with oleum ricini-induced diarrhea protection. The test was carried out by inducing mice using 0,75 mL of Ricini oleum orally first, 1 hour later given a test solution in the form of 0,5% Na CMC suspension, 0,52 mg/kgBB loperamide test solution, cowpea infusa doses of 1,5 g/kgBB, 3 g/kgBB and 6 g/kgBB. Then observations were made on the weight of diarrhea feces and the diameter of water absorption every 30 minutes for 5 hours. The results showed that cowpea infusa with doses of 1,5 g/kgBB, 3 g/kgBB and 6 g/kgBB had activity as antidiarrheal indicated by a significant difference in the test group against the negative control group (p ≤0.05).

UJI AKTIVITAS ANTIDIARE EKSTRAK DAUN KESUM (Polygonum minus Huds) TERHADAP MENCIT PUTIH JANTAN (Mus musculus): BAHASA INDONESIA Dian kartikasari; Puspita, Weni; Puspa Sari, Heni; Inderiyani, Inderiyani; Yolanda, Riska
Jurnal Insan Farmasi Indonesia Vol 7 No 3 (2024): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/a1k8h275

Diarrhea is a clinical symptom of digestive disorders which is characterized by an increase in the frequency of defecation more than usual and repeatedly accompanied by a change in the shape and consistency of the feces to become soft or liquid. The aim of this research is to determine the effect of antidiarrheal activity of extract (Polygonum minus Huds) on male white mice and to find out at what concentration of extract is needed for the antidiarrheal effect on male white mice. This research was carried out by inducing mice with oleum ricini, then giving extract, then observing the time when diarrhea occurred, stool consistency, frequency of diarrhea, and the duration of diarrhea. The results obtained showed that there was a significant difference between the positive control group, 0.25% extract, 0.5% extract and 0.75% extract against the negative control group. This indicates that the three test groups have. Then from these data it can be seen that the 0.25% extract group, 0.5% extract and 0.75% extract had no significant differences from the positive control group. This indicates that kesum leaf extract with concentrations of 0.25%, 0.5% and 0.75% has activity that is close to or similar to the positive group

POTENSI INTERAKSI OBAT-OBAT PADA RESEP POLIKLINIK PENYAKIT DALAM DI INSTALASI RAWAT JALAN RSUD DR. SOEDARSO PONTIANAK Herdaningsih, Sulastri; inderiyani, inderiyani; fauzan, suhaimi
Jurnal Ilmiah Pharmacy Vol 10, No 2 (2023)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v10i2.501

Interaksi obat merupakan salah satu drug related problems (DRP’s) yang bisa mempengaruhi outcome klinis pada pasien Banyaknya jumlah obat-obatan yang dikonsumsi dalam satu resep mempunyai kecenderungan terjadinya interaksi obat sehingga meningkatkan risiko gangguan kesehatan bagi pasien. Penelitian ini bertujuan untuk mengetahui potensi interaksi antar obat dengan obat sehingga dapat mengetahui persentase potensi interaksi obat-obat pada resep poliklinik penyakit dalam di instalasi rawat jalan RSUD Dr. Soedarso Pontianak. Metode penelitian yang digunakan adalah deskriptif retrospektif yang bertujuan untuk membuat gambaran dengan mengambil resep lampau yang dilakukan pada bulan Januari sampai dengan Maret 2022. Data diidentifikasi melalui literatur terpercaya dari website www.drugs.com atau Drug Interactions Checker. Dari hasil penelitian yang telah dilakukan didapatkan persentase potensi interaksi obat adalah sebesar 34,27%, untuk interaksi mayor sebesar 7,82%, moderat 79,78%, dan minor 12,40%.Kata Kunci : Interaksi Obat-Obat, Rumah Sakit, Penyakit Dalam

AKTIVITAS MUKOLITIK EKSTRAK ETANOL KACANG PANJANG (Vigna sinensis L.) TERHADAP PUTIH TELUR BEBEK SECARA IN VITRO Inderiyani, Inderiyani; Herdaningsih, Sulastri; Muharami, Savitri
Edu Masda Journal Vol 9, No 1 (2025): EDU MASDA JOURNAL
Publisher : STIKes Kharisma Persada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52118/edumasda.v9i1.263

ABSTRACT The long bean plant (Vigna sinensis L.) is a type of legume vegetable that is widely cultivated in Indonesia. This plant has secondary metabolites i.e alkaloids, flavonoids, saponins and tannins which are suspected to have activity as mucolytics. This study aims to find out whether ethanol extract of long beans with a concentration of 0.1%; 0.2% and 0.4% have activity as mucolytics. The research was carried out by processing seedless long beans into simplicia and then maceration with 96% ethanol solvent. Activity testing was carried out by mixing 100 mL of duck egg white with 100 mL of test solution (1:1). The test solution used was negative control (aquadest), positive control (acetylcysteine solution 0.2%), long bean ethanol extract solution with a concentration of 0.1%; 0.2% and 0.4%. Viscosity measurements were made using the LVT230 Brookfield viscometer at minutes 0, 15, 30, 45 and 60. The results showed that the positive control group and all groups of long bean ethanol extract had a significant difference from the negative control group (p<0.05) so that it could be concluded that long bean ethanol extract with a concentration of 0.1%; 0.2% and 0.4% had mucolytic activity with a percentage of mucolytic effects respectively is 41.59%; 47.17% and 53.72%. ABSTRAKTanaman kacang panjang (Vigna sinensis L.) adalah jenis sayuran kacang- kacangan yang banyak dibudidayakan di Indonesia. Tanaman ini memiliki metabolit sekunder berupa alkaloid, flavonoid, saponin dan tanin yang diduga memiliki aktivitas sebagai mukolitik. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol kacang panjang dengan konsentrasi 0,1%; 0,2% dan 0,4% memiliki aktivitas sebagai mukolitik. Penelitian dilakukan dengan mengolah kacang panjang tanpa biji menjadi simplisia kemudian di maserasi dengan pelarut etanol 96%. Pengujian aktivitas dilakukan dengan mencampurkan 100 mL putih telur bebek dengan 100 mL larutan uji (1:1). Larutan uji yang digunakan yaitu kontrol negatif berupa aquadest, kontrol positif berupa larutan asetilsistein 0,2%, larutan ekstrak etanol kacang panjang konsentrasi 0,1%; 0,2% dan 0,4%. Pengukuran viskositas dilakukan dengan menggunakan viskometer Brookfield LVT230 pada menit ke 0, 15, 30, 45 dan 60. Hasil penelitian menunjukkan kelompok kontrol positif dan semua kelompok ekstrak etanol kacang panjang memiliki perbedaan yang bermakna terhadap kelompok kontrol negatif (p<0,05) sehingga dapat disimpulkan ekstrak etanol kacang panjang dengan konsentrasi 0,1%; 0,2% dan 0,4% memiliki aktivitas mukolitik dengan aktivitas tertinggi terdapat pada konsentrasi 0,4% yaitu sebesar 53,72%.

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